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2627-69-2 - 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98% - Acadesine - AICAR - J64720 - Alfa Aesar

J64720 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98%

Número CAS
2627-69-2
Nombre Alternativo
Acadesine
AICAR

Tamaño Precio ($) Cantidad Disponibilidad
50mg 112,50
200mg 290,77
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5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98%

MDL
MFCD00869751
EINECS
220-097-5

Propiedades químicas

Fórmula
C9H14N4O5
Peso molecular
258.23
Formulario
Powder
Punto de fusión
214-215°
Solubilidad
Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml

Aplicaciones

5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Notas

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Referencias documentales

Lee A. Witters. The blooming of the French lilac. J Clin Invest. 2001, 108, (8), 1105-1107.

Yu, X.; McCorkle, S.; Wang, M.; Lee, Y.; Li, J.; Saha, A.K.; Unger, R.H.; Ruderman, N.B. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia. 2004, 47, (11), 2012-2021.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,16
Código de tarifa arancelaria unificado
2934.99
TSCA
Yes

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