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Acetylene-PEG4-maleimide - 3-(N-maleimidyl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)propionamide - J64859 - Alfa Aesar

J64859 Acetylene-PEG4-maleimide

Número CAS
Nombre Alternativo
3-(N-maleimidyl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)propionamide

Tamaño Precio ($) Cantidad Disponibilidad
25mg 105,00
100mg 225,70
500mg 840,00
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Acetylene-PEG4-maleimide

MDL
MFCD22380740

Propiedades químicas

Fórmula
C18H26N2O7
Peso molecular
382.41
Formulario
Viscous liquid or solid
Solubilidad
Soluble in water.

Aplicaciones

Heterobifunctional cross linker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. A bifunctional linker with sulfhydryl reactive and azide reactive groups. Contains a PEG spacer to increase solubility

Notas

Keep container tightly closed. Store away from oxidizing agents.

Referencias documentales

Hao Jiang.; Tianqing Zheng.; Aime Lopez-Aguilar.; Lei Feng.; Felix Kopp.; Florence L. Marlow.; Peng Wu. Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem. 2014, 25, (4), 698-706.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Código de tarifa arancelaria unificado
2925.29
TSCA
No

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