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51050-59-0 - 3,4-Dichloroisocoumarin, 99% - 3,4-Dichloro-2-benzopyran-1-one - 3,4-DCI - J65198 - Alfa Aesar

J65198 3,4-Dichloroisocoumarin, 99%

Número CAS
51050-59-0
Nombre Alternativo
3,4-Dichloro-2-benzopyran-1-one
3,4-DCI

Tamaño Precio ($) Cantidad Disponibilidad
10mg 246,00
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3,4-Dichloroisocoumarin, 99%

MDL
MFCD00036960

Propiedades químicas

Fórmula
C9H4Cl2O2
Peso molecular
215.03
Formulario
Powder
Solubilidad
Soluble in DMF or DMSO at a concentration of 10mM

Aplicaciones

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. It is an inhibitor of Chymotrypsin and Trypsin. ,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases.

Notas

Effective concentration 5-100 M. 3,4-DCI has a half life of 20 minutes at pH 7.5.

Referencias documentales

Nadia Korfali; Elizabeth A L Fairley; Selene K Swanson; Laurence Florens; Eric C Schirmer. Use of sequential chemical extractions to purify nuclear membrane proteins for proteomics identification. Methods in Molecular Biology. 2009, 528, 201-225.

J W Harper; K Hemmi; J C Powers. Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor. Biochemistry (Washington). 1985, 24, (8), 1831-1841.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280a-P301+P310a-P305+P351+P338-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
6802625
Clase de peligro
6.1
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2932.20
TSCA
No

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