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128-53-0 - N-Ethylmaleimide, 98+% - 1-Ethyl-1H-pyrrole-2,5-dione - NEM - L00355 - Alfa Aesar

L00355 N-Ethylmaleimide, 98+%

Número CAS
128-53-0
Nombre Alternativo
1-Ethyl-1H-pyrrole-2,5-dione
NEM

Tamaño Precio ($) Cantidad Disponibilidad
10g 70,04
50g 232,78
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N-Ethylmaleimide, 98+%

MDL
MFCD00005509
EINECS
204-892-4

Propiedades químicas

Fórmula
C6H7NO2
Peso molecular
125.13
Punto de fusión
43-46°
Punto de ebullición
209-211°
Punto de inflamabilidad
73°(163°F)
Sensibilidad
Light Sensitive
Solubilidad
Soluble in ethanol, water, chloroform, methanol and toluene.

Aplicaciones

Cysteine alkylating agent N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg<sup>2+</sup-dependent internucleosomal DNA fragmentation.

Notas

Light sensitive. Store in cool place. Incompatible with strong oxidizing agents, strong acids and strong bases.

Referencias documentales

Reactive dienophile and dipolarophile. Reagent for modification of sulfhydryl groups of cysteine residues in proteins: Methods Enzymol., 25, 449 (1972); Eur. J. Biochem., 145, 245 (1984).

Shah, N.; Colbert, K. N.; Enos, M. D.; Herschlag, D.; Weis, W. I. Three alpha-SNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF). J. Biol. Chem. 2015, 290 (4), 2175-2188.

Iwasaki, F.; Suga, K.; Umakoshi, H. Pseudo-Interphase of Liposome Promotes 1, 3-Dipolar Cycloaddition Reaction of Benzonitrile Oxide and N-Ethylmaleimide in Aqueous Solution. J. Phys. Chem. B 2015, 119, (30), 9772-9779.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H300-H311-H317-H314-H318

Fatal if swallowed. Toxic in contact with skin. May cause an allergic skin reaction. Causes severe skin burns and eye damage. Causes serious eye damage.

Indicaciones de precaución: P260-P261-P280-P301+P310-P303+P361+P353-P305+P351+P338-P361-P301+P330+P331-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,3822
Beilstein
112448
Clase de peligro
6.1
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2925.19
TSCA
Yes
RTECS
UX9625000

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