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33884-43-4 - 2-(2-Bromoethyl)-1,3-dioxane, 98% - 2-Bromopropanal 1,3-propanediol acetal - 2-Bromopropionaldehyde trimethylene acetal - L00958 - Alfa Aesar

L00958 2-(2-Bromoethyl)-1,3-dioxane, 98%

Número CAS
33884-43-4
Nombre Alternativo
2-Bromopropanal 1,3-propanediol acetal
2-Bromopropionaldehyde trimethylene acetal

Tamaño Precio ($) Cantidad Disponibilidad
10g 26,10
50g 88,90
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2-(2-Bromoethyl)-1,3-dioxane, 98%

MDL
MFCD00006567
EINECS
251-716-7

Propiedades químicas

Fórmula
C6H11BrO2
Peso molecular
195.06
Punto de ebullición
67-70°/3mm
Punto de inflamabilidad
96°(204°F)
Densidad
1.434
Índice de refracción
1.4820
Solubilidad
It is not soluble in water but soluble in organic solvent such as ethanol.

Aplicaciones

2-(2-Bromoethyl)-1,3-dioxane, Provides a useful means of introducing a masked ß-formylethyl group. In comparison with the corresponding dioxolane (following entry), the dioxane is more stable to acid, and the Grignard is thermally stable. Reaction of the Grignard with an acid chloride gives the ketone in high yield without further reaction to the tertiary alcohol. Subsequent hydrolysis of the 1,3-dioxane gives the -ketoaldehyde. It is also used as a pharmaceutical intermediate.

Notas

Air, Heat sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

Referencias documentales

JC Stowell. New. gamma.-keto Aldehyde synthesis. The Journal of Organic Chemistry. 197641(3) , 560-561.

A Fadel.; P Arzel. Asymmetric construction of benzylic quaternary carbons by lipase-mediated enantioselective transesterification of prochiral α, α-disubstituted 1, 3-propanediols. Tetrahedron: Asymmetry. 19978(2) , 283-291.

Provides a useful means of introducing a masked ß-formylethyl group. In comparison with the corresponding dioxolane (following entry), the dioxane is more stable to acid, and the Grignard is thermally stable. Reaction of the Grignard with an acid chloride gives the ketone in high yield without further reaction to the tertiary alcohol. Subsequent hydrolysis of the 1,3-dioxane gives the -ketoaldehyde: J. Org. Chem., 41, 560 (1976).

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
1421628
Código de tarifa arancelaria unificado
2932.99
TSCA
Yes

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