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50-28-2 - beta-Estradiol, 99% (dry wt.), ca 3% water - (8R,9S,13S,14S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol - L03801 - Alfa Aesar

L03801 beta-Estradiol, 99% (dry wt.), ca 3% water

Número CAS
50-28-2
Nombre Alternativo
(8R,9S,13S,14S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Tamaño Precio ($) Cantidad Disponibilidad
1g 34,90
5g 123,00
25g 476,00
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beta-Estradiol, 99% (dry wt.), ca 3% water

MDL
MFCD00003693
EINECS
200-023-8

Propiedades químicas

Fórmula
C18H24O2
Peso molecular
272.39
Punto de fusión
175-178°
Solubilidad
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.

Aplicaciones

β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.

Notas

Incompatible with strong oxidizing agents.

Referencias documentales

Liu, X.; Liu, Y.; Cheng, M.; Zhang, X.; Xiao, H. A metabolomics study of the inhibitory effect of 17-beta-estradiol on osteoclast proliferation and differentiation. Mol. Biosyst. 2015, 11 (2), 635-646.

Pooley, A. E.; Luong, M.; Hussain, A.; Nathan, B. P. Neurite outgrowth promoting effect of 17-beta estradiol is mediated through estrogen receptor alpha in an olfactory epithelium culture. Brain Res. 2015, 1624, 19-27.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H350-H360

May cause cancer. May damage fertility or the unborn child.

Indicaciones de precaución: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,3703
Beilstein
1914275
Código de tarifa arancelaria unificado
2906.19
TSCA
No
RTECS
KG2975000

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