Cookies disclaimer

Estoy de acuerdo utilizamos cookies para mejorar la experiencia de navegación del usuario y para estudiar cómo se utiliza nuestro sitio web. si navega por nuestro sitio web, estará aceptando el uso de las cookies en las condiciones establecidas en la presente política de cookies. esta política puede ser actualizada, por lo que le invitamos a revisarla de forma regular

78-39-7 - Triethyl orthoacetate, 98% - Ethyl orthoacetate - Orthoacetic acid triethyl ester - L06004 - Alfa Aesar

L06004 Triethyl orthoacetate, 98%

Número CAS
78-39-7
Nombre Alternativo
Ethyl orthoacetate
Orthoacetic acid triethyl ester

Tamaño Precio ($) Cantidad Disponibilidad
100ml 30,95
500ml 86,67
2500ml 283,25
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

Triethyl orthoacetate, 98%

MDL
MFCD00009223
EINECS
201-112-4

Propiedades químicas

Fórmula
CH3C(OCH2CH3)3
Peso molecular
162.23
Punto de ebullición
142-143°
Punto de inflamabilidad
32°(89°F)
Densidad
0.887
Índice de refracción
1.3970
Sensibilidad
Moisture Sensitive
Solubilidad
Slightly miscible with water.

Aplicaciones

Triethyl orthoacetate is used as pharmaceutical and water scavenger. It is also used in organic synthesis to introduce the acetate group into an alcohol. It is involved in the Johnson-Claisen rearrangement.

Notas

Moisture sensitive. Incompatible with strong oxidizing agents.

Referencias documentales

Reagent for facile esterification of sulfonic and carboxylic acids: Tetrahedron Lett., 34, 7355 (1993).

The products with allylic alcohols undergo Claisen allyl ether rearrangement, with addition of a 2-carbon unit and repositioning of the double bond: J. Am. Chem. Soc., 92, 741 (1970); Tetrahedron Lett., 21, 1285 (1980):

For further examples, see: Org. Synth. Coll., 6, 584 (1988); 7, 164 (1990).

Reaction with BF3 etherate gives the moderately stable selective alkylating agent, methyl diethoxycarbenium tetrafluoroborate: Synth. Commun., 19, 2307 (1989). Compare Triethyl­ orthoformate, A13587.

Under mild acid catalysis, reacts with ethynyl alcohols to give allenic esters, which can be conjugated over alumina. For examples, see: Org. Synth. Coll., 8, 251 (1993):

Yang, J.; Su, G.; Ren, Y.; Chen, Y. Design, synthesis and evaluation of isoxazolo [5, 4-d] pyrimidin-4 (5H)-one derivatives as antithrombotic agents. Bioorg. Med. Chem. Lett. 2015, 25 (3), 492-495.

Shawali, A. S.; Sami, A. Annulated 3-Amino-4-Imino-Pyrimidines: Their Utility as Useful Precursors for the Synthesis of Fused Heterocycles. Curr. Org. Synth. 2015, 12 (4), 391-430.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
506201
Clase de peligro
3
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2915.39
TSCA
Yes
RTECS
KJ4075000

Recomendado

Visto recientemente

Productos químicos

Ciencias de la vida

Metales & materiales

Catalizadores

Análisis y material de laboratorio