5-Methylindole is used as reactant for preparation of pharmaceutically active 2-oxo-1-pyrrolidine analogues, potential anticancer immunomodulators, IL2-inducible T-cell kinase (ITK) inhibitors and CRTh2 antagonists.
Ran Jiang; Hai-Yan Xu; Xiao-Ping Xu; Xue-Qiang Chu; Shun-Jun Ji. Direct alkylation of indoles and amines by tert-enamides: facile access to pharmaceutically active 2-oxo-1-pyrrolidine analogues. Organic & Biomolecular Chemistry. 2011, 9,(16), 5659-5669.
Eduard Dolusic; Pierre Larrieu; Laurence Moineaux; Vincent Stroobant; Luc Pilotte; Didier Colau; Lionel Pochet; Benoit Van den Eynde; Bernard Masereel; Johan Wouters; Raphael Frederick. Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. Journal of medicinal and pharmaceutical chemistry. 2011, 54,(15), 5320-5334.
Indicaciones de peligro (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Indicaciones de precaución: P260-P201-P280g-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.