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677-43-0 - N,N-Dimethylphosphoramidodichloridate, 97% - Dimethylaminophosphoryl dichloride - N,N-Dimethylphosphoramic dichloride - L07231 - Alfa Aesar

L07231 N,N-Dimethylphosphoramidodichloridate, 97%

Número CAS
677-43-0
Nombre Alternativo
Dimethylaminophosphoryl dichloride
N,N-Dimethylphosphoramic dichloride

Tamaño Precio ($) Cantidad Disponibilidad
5g 45,63
25g 144,20
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N,N-Dimethylphosphoramidodichloridate, 97%

MDL
MFCD00013896
EINECS
211-641-2

Propiedades químicas

Fórmula
C2H6Cl2NOP
Peso molecular
161.96
Punto de ebullición
89-90°/20mm
Punto de inflamabilidad
>110°(230°F)
Densidad
1.360
Índice de refracción
1.4630
Sensibilidad
Moisture Sensitive
Solubilidad
Miscible with dimethoxyethane.

Aplicaciones

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.

Notas

Moisture and air sensitive. Hygroscopic. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Referencias documentales

With 1,2-diols forms cyclic phosphoric amides which can be reduced to alkenes, e.g. with Na in xylene: Synth. Commun., 5, 293 (1975).

In the presence of pyridine, carboxylic acids form active intermediates which react with alcohols in situ to give esters: Tetrahedron Lett., 4461 (1978). Has also been used to convert primary alcohols to alkyl chlorides: Chem. Lett., 923 (1978).

Wils, E. R. Mass spectral data of precursors of chemical warfare agents. Fresenius J. Anal. Chem. 1990, 338 (1), 22-27.

Santilli, A. A.; Morris, R. L.; Scotese, A. C.; Strike, D. P. A convenient synthesis of N-[2-[[[5-[(dimethlamino methyl]-2-furanylmethyl]thio]ethyl]thieno-[3, 4-d]isothiazol-3-amine-1,1-dioxide hydrochloride,a potent gastric acid antisecretory agent. Org. Prep. Proced. Int. 1990, 22 (1), 71-76.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Indicaciones de precaución: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
969956
Clase de peligro
8
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2931.90
TSCA
No
RTECS
TB4025000

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