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17145-91-4 - Triethyl 2-phosphonobutyrate, 97% - Diethyl 1-(ethoxycarbonyl)propanephosphonate - 2-Phosphonobutyric acid triethyl ester - L09329 - Alfa Aesar

L09329 Triethyl 2-phosphonobutyrate, 97%

Número CAS
17145-91-4
Nombre Alternativo
Diethyl 1-(ethoxycarbonyl)propanephosphonate
2-Phosphonobutyric acid triethyl ester

Tamaño Precio ($) Cantidad Disponibilidad
5g 35,74
25g 109,14
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Triethyl 2-phosphonobutyrate, 97%

MDL
MFCD00041347

Propiedades químicas

Fórmula
C10H21O5P
Peso molecular
252.25
Punto de ebullición
105-106°/2mm
Punto de inflamabilidad
>110°(230°F)
Densidad
1.064
Índice de refracción
1.4330
Solubilidad
Not miscible or difficult to mix with water.

Aplicaciones

Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.

Notas

Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Referencias documentales

Yuan Cheng et. al. From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).. Journal of medicinal and pharmaceutical chemistry,2011, 54 (16), 5836-5857.

Shintaro Ban et. al. Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists. Bioorganic & Medicinal Chemistry,2011, 19(10), 3183-3191.

Intermediate for Wadsworth-Emmons formation of ɑ-ethylacrylic esters. See Appendix 1.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Indicaciones de precaución: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Otras referencias

Beilstein
1789280
Código de tarifa arancelaria unificado
2931.90
TSCA
No

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