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69304-37-6 - 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97% - L11171 - Alfa Aesar

L11171 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%

Número CAS
69304-37-6
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
1g 51,40
5g 171,00
25g 547,00
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1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%

MDL
MFCD00009655
EINECS
000-000-0

Propiedades químicas

Fórmula
C12H28Cl2OSi2
Peso molecular
315.43
Punto de ebullición
69-70°/0.5mm
Punto de inflamabilidad
>110°(230°F)
Densidad
0.986
Índice de refracción
1.4540
Sensibilidad
Moisture Sensitive
Solubilidad
Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.

Aplicaciones

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.

Notas

Incompatible with strong oxidizing agents and water.

Referencias documentales

Reagent for the protection of diols, including carbohydrate-type molecules, as their 1,3-(1,1,3,3-tetraisopropyldisiloxanylidene) (TIPDS) derivatives, formed in the presence of imidazole: J. Chem. Res. Synop., 24 (1979); J. Org. Chem., 50, 1651 (1985), or pyridine-DMF: Tetrahedron, 41, 4545, 4557 (1985). The high steric demand of the TIPDS group enables discrimination between primary and secondary OH. It is readily cleaved by F- (e.g. TBAF in THF) or by aqueous acid or base. See Appendix 4.

Osawa, T.; Hari, Y.; Dohi, M.; Matsuda, Y.; Obika, S. Synthesis and Properties of the 5-Methyluridine Derivative of 3,4-Dihydro-2H-pyran-Bridged Nucleic Acid (DpNA). J. Org. Chem. 2015, 80 (21), 10474-10481.

Clobes, C.; Jerabek, P.; Nußbruch, I.; Frenking, G.; von Hänisch, C. Stepwise Synthesis of Siloxane-Substituted Oligoarsanes and Structural Investigation of Alkaline Earth Metal Derivatives. Eur. J. Inorg. Chem. 2015, 2015 (20), 3264-3273.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Indicaciones de precaución: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
1934216
Clase de peligro
8
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2931.90
TSCA
No

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