Cookies disclaimer

Estoy de acuerdo utilizamos cookies para mejorar la experiencia de navegación del usuario y para estudiar cómo se utiliza nuestro sitio web. si navega por nuestro sitio web, estará aceptando el uso de las cookies en las condiciones establecidas en la presente política de cookies. esta política puede ser actualizada, por lo que le invitamos a revisarla de forma regular

70384-51-9 - Tris(3,6-dioxaheptyl)amine, 95% - TDA-1 - Tris[2-(2-methoxyethoxy)ethyl]amine - L13544 - Alfa Aesar

L13544 Tris(3,6-dioxaheptyl)amine, 95%

Número CAS
70384-51-9
Nombre Alternativo
TDA-1
Tris[2-(2-methoxyethoxy)ethyl]amine

Tamaño Precio ($) Cantidad Disponibilidad
5g 11,20
25g 37,40
100g 93,60
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

Tris(3,6-dioxaheptyl)amine, 95%

MDL
MFCD00010748
EINECS
274-590-5

Propiedades químicas

Fórmula
N(CH2CH2OCH2CH2OCH3)3
Peso molecular
323.43
Punto de fusión
<-100°
Punto de ebullición
163-171°/1mm
Punto de inflamabilidad
162°(323°F)
Densidad
1.011
Índice de refracción
1.4486
Sensibilidad
Air Sensitive & Hygroscopic
Solubilidad
Miscible with water.

Aplicaciones

Tris(3,6-dioxaheptyl)amine acts as a phase transfer catalyst used in the preparation of 1,3-dideaza-2'-deoxyadenosine and related benzimidazole 2'-deoxyribonucleosides. It is also used as an intermediate in the synthesis of telithromycin. Further, it is used in the oxidation of arylmethanols under phase-transfer conditions. In addition to this, it acts as a cryptand during phase-transfer glycosylation of 2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine.

Notas

Air sensitive and hygroscopic. Incompatible strong oxidizing agents and strong acids.

Referencias documentales

Acyclic solid-liquid phase-transfer catalyst (see Appendix 2).

Solubilizes salts of alkali metals and of transition metals, e.g. PdCl2, RuCl3 and RhCl3, allowing these to be used in hydrogenation reactions: Synth. Commun., 19, 2833 (1989).

Forms isolable 2:1 complexes with Grignard reagents: Tetrahedron, 45, 171 (1989).

Accelerates dehydrobromination of alkyl halides in the presence of KOH: Org. Synth. Coll., 9, 539 (1998). For use in the Wittig reaction, see Cyclopropyl­triphenyl­phosphonium bromide, B25102.

Has been used in a number of aromatic nucleophilic substitution reactions:

In studies of solvent-free SNAr reactions, TDA-1 was found to be the best catalyst: Synth. Commun., 20, 2855 (1990); Heterocycles, 32, 1947 (1991). In combination with CuCl, is also a useful catalyst in the Ullmann aryl ether synthesis: J. Org. Chem., 50, 3717 (1985). An improved N-arylation of amides utilizes a catalyst combination of CuCl and TDA-1 (5:1): Synthesis, 312 (1989).

For use in a stereospecific glycosylation reaction of a pyrimidine base, see: Helv. Chim. Acta, 71, 1573 (1988).

Quick, M. P.; Wünsch, B. Synthesis of hydrogenated 2-benzazepin-1-ones by the addition of aryllithium intermediates to isocyanates. Tetrahedron: Asymmetry 2015, 26 (5-6), 276-280.

Li, H.; Pang, Z.; Gao, P.; Wang, L. Fe(III)-catalyzed grafting copolymerization of lignin with styrene and methyl methacrylate through AGET ATRP using triphenyl phosphine as a ligand. RSC Adv. 2015, 5 (67), 54387-54394.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Indicaciones de precaución: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Otras referencias

Beilstein
2369296
Código de tarifa arancelaria unificado
2922.19
TSCA
Yes

Recomendado

Visto recientemente

Productos químicos

Ciencias de la vida

Metales & materiales

Catalizadores

Análisis y material de laboratorio