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7202-43-9 - (R)-(-)-Tetrahydrofurfurylamine, 98+% - (R)-(-)-2-(Aminomethyl)tetrahydrofuran - L14410 - Alfa Aesar

L14410 (R)-(-)-Tetrahydrofurfurylamine, 98+%

Número CAS
7202-43-9
Nombre Alternativo
(R)-(-)-2-(Aminomethyl)tetrahydrofuran

(R)-(-)-Tetrahydrofurfurylamine, 98+%

MDL
MFCD00192476

Propiedades químicas

Fórmula
C5H11NO
Peso molecular
101.15
Punto de ebullición
152-153°
Punto de inflamabilidad
45°(113°F)
Densidad
0.980
Índice de refracción
1.4550
Sensibilidad
Hygroscopic
Solubilidad
Fully miscible with water.

Aplicaciones

(R)-(-)-Tetrahydrofurfurylamine is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors.

Notas

Hygroscopic, store away from water/moisture. Store in cool. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Referencias documentales

Liu, G. et al. Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors. J. Med. Chem. 2007, 50 (13), 3086-3100.

Piotr Przybylski; Magdalena Włodarz; Bogumil Brzezinski; Franz Bartl. Spectroscopic studies and PM5 semiempirical calculations of tautomeric forms of gossypol schiff base with (R)-tetrahydrofurfurylamine. Journal of Molecular Structure. 2004, 691 (1-3), 227-234.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318-H226

Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour.

Indicaciones de precaución: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
4652873
Clase de peligro
3
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2932.19
TSCA
No

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