Cookies disclaimer

Estoy de acuerdo utilizamos cookies para mejorar la experiencia de navegación del usuario y para estudiar cómo se utiliza nuestro sitio web. si navega por nuestro sitio web, estará aceptando el uso de las cookies en las condiciones establecidas en la presente política de cookies. esta política puede ser actualizada, por lo que le invitamos a revisarla de forma regular

4039-32-1 - Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene, packaged in resealable septum cap bottle - LHMDS - Lithium hexamethyldisilazide - L15012 - Alfa Aesar

L15012 Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene, packaged in resealable septum cap bottle

Número CAS
4039-32-1
Nombre Alternativo
LHMDS
Lithium hexamethyldisilazide

Tamaño Precio ($) Cantidad Disponibilidad
100ml 79,70
500ml 248,00
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene, packaged in resealable septum cap bottle

MDL
MFCD00008261
EINECS
223-725-6

Propiedades químicas

Fórmula
C6H18LiNSi2
Peso molecular
167.33
Punto de inflamabilidad
-17°(1°F)
Densidad
0.891
Sensibilidad
Air & Moisture Sensitive
Solubilidad
Reacts with water.

Aplicaciones

Lithium bis(trimethylsilyl)amide is used in generating enolates for preparing lactone precursors, pyranones, and cyclohexanes. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines and in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles. It is also used in the lithiation of ethyl acetate and in the stereospecific Wadsworth-Emmons synthesis of fluoroalkenes from (E)- and (Z)-fluorovinyl sulfones.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. Incompatible with oxidizing agents.

Referencias documentales

Bert Y. Kimura.; Theodore L. Brown. Solvent effects on the aggregation of lithium bis(trimethylsilyl)amide. Journal of Organometallic Chemistry. 1971, 26 (1), 57-67.

Sunwoo Lee.; Morten Jørgensen.; John F. Hartwig. Palladium-Catalyzed Synthesis of Arylamines from Aryl Halides and Lithium Bis(trimethylsilyl)amide as an Ammonia Equivalent. Org. Lett. 2001, 3 (17), 2729-2732.

Supplied in septum cap bottle.

Versatile non-nucleophilic strong base. For examples of use in the lithiation of ethyl acetate, see: Org. Synth. Coll., 6, 598 (1988), and in the stereospecific Wadsworth-Emmons synthesis of fluoroalkenes from (E)- and (Z)-fluorovinyl sulfones: Org. Synth. Coll., 9, 442 (1998).

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H225-H303-H333-H314-H318-H351-H335-H373

Highly flammable liquid and vapour. May be harmful if swallowed. May be harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of causing cancer. May cause respiratory irritation. May cause damage to organs through prolonged or repeated exposure.

Indicaciones de precaución: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
8136861
Clase de peligro
3
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2931.90
TSCA
Yes

Recomendado

  • A10249

    Tetra-n-butylammonium bromide, 98+%
  • A10265

    Biphenyl, 99%
  • A11766

    Allyl bromide, 99%, stab. with 300-1000ppm Propylene oxide
  • A11767

    Trifluoromethanesulfonic anhydride, 98%
  • A13651

    Chlorotrimethylsilane, 98+%

Visto recientemente

Productos químicos

Ciencias de la vida

Metales & materiales

Catalizadores

Análisis y material de laboratorio