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520-36-5 - 4',5,7-Trihydroxyflavone, 97% - Apigenin - L15041 - Alfa Aesar

L15041 4',5,7-Trihydroxyflavone, 97%

Número CAS
520-36-5
Nombre Alternativo
Apigenin

Tamaño Precio ($) Cantidad Disponibilidad
25mg 44,50
100mg 120,00
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4',5,7-Trihydroxyflavone, 97%

MDL
MFCD00006831
EINECS
208-292-3

Propiedades químicas

Fórmula
C15H10O5
Peso molecular
270.24
Punto de fusión
ca 315° dec.
Solubilidad
Soluble in dimethyl sulfoxide (27 mg/ml) or 1M potassium hydroxide (50mg/ml).

Aplicaciones

4',5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with and strong oxidizing agents.

Referencias documentales

Hirano T.; Oka K.; Akiba M. Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Research Communications in Chemical Pathology and Pharmacology. 1989, 64 (1), 69-78.

Sunanda Panda.; Anand Kar. Apigenin (4‘,5,7-trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. Journal of Pharmacy and Pharmacology. 2007, 59 (11), 1543-1548.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,730
Beilstein
262620
Código de tarifa arancelaria unificado
2932.99
TSCA
No
RTECS
LK9276000

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