4-Iodobenzylamine hydrochloride is used to prepare cyclic amide by reacting with methyl 4-bromomethyl-3-methoxycarbonylcinnamate in the presence of triethylamine. It is also used in pharmaceuticals, agrochemicals and dye industries.
Strack, M.; Langklotz, S.; Bandow, J. E.; Metzler-Nolte, N.; Albada, H. B. Silyl-Based Alkyne-Modifying Linker for the Preparation of C-Terminal Acetylene-Derivatized Protected Peptides. J. Org. Chem. 2012, 77 (22), 9954-9958.
Wijtmans, M.; Verzijl, D.; Bergmans, S.; Lai, M.; Bosch, L.; Smit, M. J.; de Esch, I. J. P.; Leurs, R. CXCR3 antagonists: Quaternary ammonium salts equipped with biphenyl- and polycycloaliphatic-anchors. Bioorg. Med. Chem. 2011, 19 (11), 3384-3393.
Indicaciones de peligro (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Indicaciones de precaución: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.