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67-51-6 - 3,5-Dimethyl-1H-pyrazole, 99% - A10157 - Alfa Aesar

A10157 3,5-Dimethyl-1H-pyrazole, 99%

Numéro CAS
67-51-6
Synonymes

Dimensions Prix ($) Quantité Disponibilité
50g 29,87
250g 112,88
1000g 215,20
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3,5-Dimethyl-1H-pyrazole, 99%

MDL
MFCD00005243
EINECS
200-657-5

Propriétés chimiques

Formule
C5H8N2
Poids formulaire
96.13
Point de fusion
105-108°
Point d'ébullition
218°
Solubilité
Soluble in water, methanol 0.1 g/mL.

Applications

3,5-Dimethyl-1H-pyrazole is combined with Chromium(VI)­ oxide, is a valuable reagent for oxidation of primary and secondary alcohols to carbonyl compounds. It reacts with malonic esters gives a family of cross-conjugated monomeric betaines. It is a common reagent for the preparation of pyrazolato ligated complexes. It is also used to prepare N-1-substituted derivatives having antibacterial activity.

Notes

Store away from oxidizing agents. Store in a cool, dry condition in well sealed containers.

Références bibliographiques

Hasnae Bendaha; Lisa Yu; Rachid Touzani; Rachid Souane; Guri Giaever; Corey Nislow; Charles Boone; Sghir El Kadiri; Grant W. Brown; Mohammed Bellaoui. New azole antifungal agents with novel modes of action: Synthesis and biological studies of new tridentate ligands based on pyrazole and triazole. European Journal of Medicinal Chemistry. 2011, 46 (9), 4117-4124.

F Castro González; A Martínez Garza. Comparative study of analgesics. Practica odontologica. 1986, 7 (2), 30-34.

The combination with Chromium(VI)­ oxide, 12522 is a valuable reagent for oxidation of primary and secondary alcohols to carbonyl compounds in very high yields: Tetrahedron Lett., 4499 (1973). With Pyridinium chlorochromate, A11752, allylic alcohols are oxidized selectively in the presence of secondary alcohols: J. Org. Chem., 48, 4766 (1983).

Reaction of pyrazoles with malonic esters gives a family of cross-conjugated monomeric betaines: Synthesis, 629 (1989):

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
106325
Code tarifaire harmonisé
2933.19
TSCA
Yes
RTECS
UQ6477600

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Analytique et matériel de laboratoire