Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

110-91-8 - Morpholine, 99% - A10355 - Alfa Aesar

A10355 Morpholine, 99%

Numéro CAS
110-91-8
Synonymes

Dimensions Prix ($) Quantité Disponibilité
100g 18,54
500g 29,89
2500g 86,21
Ajouter au panier Ajouter au devis en vrac Afficher l'article

Morpholine, 99%

MDL
MFCD00005972
EINECS
203-815-1

Propriétés chimiques

Formule
C4H9NO
Poids formulaire
87.12
Point de fusion
-5°
Point d'ébullition
129°
Point d'éclair
35°(95°F)
Densité
1.007
Indice de réfraction
1.4540
Sensibilité
Hygroscopic
Solubilité
Miscible with water.      

Applications

Morpholine is a common additive for pH adjustment in both fossil fuel and nuclear power plant steam systems. It is widely used in organic synthesis as a building block in the preparation of the antibiotic linezolid, the anticancer agent gefitinib and the analgesic dextromoramide. It is also used as a solvent in chemical reactions and in the preparation of enamines. Further, it serves as a chemical emulsifier in the process of waxing fruit.

Notes

Hygroscopic. Incompatible with strong oxidizing agents.

Références bibliographiques

Reagent for the cleavage of Fmoc protecting groups in peptide synthesis (see 9-Fluorenyl­methyl­ chloroformate, A11683): J. Am. Chem. Soc., 92, 5748 (1970); J. Org. Chem., 37, 3404 (1972). See Appendix 6 for peptide reagents.

In the Kindler modification of the Willgerodt reaction, aryl ketones are converted to ω-arylalkanoic acids by reaction with sulfur and an amine, usually morpholine: Org. Synth. Coll., 9, 99 (1998); reviews: Org. React., 3, 83 (1946); Synthesis, 358 (1975).

Lithium morpholide adds to aromatic aldehydes at low temperature, a useful means for the protection of the aldehyde group in lithiations: Tetrahedron Lett., 25, 4213 (1981); J. Org. Chem., 48, 2356 (1983).

Chlorination with hypochlorite gives N-chloromorpholine, a useful reagent in strongly acid media for the selective chlorination of activated aromatics: Org. Synth. Coll., 8, 167 (1993), and references therein.

Chen, D.; Miao, H.; Zou, J.; Cao, P.; Ma, N.; Zhao, Y.; Wu, Y. Novel Dispersive Micro-Solid-Phase Extraction Combined with Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry To Determine Morpholine Residues in Citrus and Apples. J. Agric. Food. Chem. 2015, 63 (2), 485-492.

Ye, L.; Zhai, L.; Fang, J.; Liu, J.; Li, C.; Guan, R. Synthesis and characterization of novel cross-linked quaternized poly (vinyl alcohol) membranes based on morpholine for anion exchange membranes. Solid State Ionics 2013, 240, 1-9.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H226-H302-H312-H332

Causes severe skin burns and eye damage. Flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Mentions de prudence: P210-P260-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,6277
Beilstein
102549
Classe de danger
8
Groupe d'emballage
I
Code tarifaire harmonisé
2934.99
TSCA
Yes
RTECS
QD6475000

Recommandé

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire