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100-55-0 - 3-Pyridinemethanol, 98% - 3-(Hydroxymethyl)pyridine - Nicotinyl alcohol - A10381 - Alfa Aesar

A10381 3-Pyridinemethanol, 98%

Numéro CAS
100-55-0
Synonymes
3-(Hydroxymethyl)pyridine
Nicotinyl alcohol

Dimensions Prix ($) Quantité Disponibilité
50g 32,96
250g 102,40
1000g 356,00
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3-Pyridinemethanol, 98%

MDL
MFCD00006407
EINECS
202-864-6

Propriétés chimiques

Formule
C6H7NO
Poids formulaire
109.13
Point de fusion
-8 to -6°
Point d'ébullition
154°/28mm
Point d'éclair
149°(300°F)
Densité
1.130
Indice de réfraction
1.5450
Sensibilité
Hygroscopic
Solubilité
Fully miscible in water.

Applications

3-Pyridinemethanol is a useful synthetic intermediate. Among other uses, it has been used in the synthesis of histone deacetylase inhibitors. It is also used to solubilize riboflavin and as a peripheral vasodilator; alcohol analog of nicotinic acid; a direct-acting peripheral vasodilator that is used in vasospasm and threatened gangrene.

Notes

Hygroscopic. Store away from oxidizing agents and water/moisture. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.

Références bibliographiques

Zane N. Gaut, et al. Effects of Large Doses of Nicotinyl Alcohol on Serum Lipid Levels and Carbohydrate Tolerance. The Journal of Clinical Pharmacology and The Journal of New Drugs.,1968,8(6), 370-376.

V. Arjunan, et al. A comparative study on vibrational, conformational and electronic structure of 2-(hydroxymethyl)pyridine and 3-(hydroxymethyl)pyridine.J. Mol. Struct.,2012,1018156-170.

3-Picolyl esters can be prepared by carbodiimide coupling and have been used for protection of the side chain carboxyl groups of aspartic and glutamic acids in peptide synthesis: J. Org. Chem., 53, 5386 (1988). See Appendix 6.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,6527
Beilstein
107851
Code tarifaire harmonisé
2933.39
TSCA
Yes
RTECS
UT4690000

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