Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

429-41-4 - Tetra-n-butylammonium fluoride, 1M soln. in THF - TBAF - A10588 - Alfa Aesar

A10588 Tetra-n-butylammonium fluoride, 1M soln. in THF

Numéro CAS
429-41-4
Synonymes
TBAF

Dimensions Prix ($) Quantité Disponibilité
25ml 32,30
100ml 59,40
500ml 192,00
Ajouter au panier Ajouter au devis en vrac Afficher l'article

Tetra-n-butylammonium fluoride, 1M soln. in THF

MDL
MFCD00011747
EINECS
207-057-2

Propriétés chimiques

Formule
C16H36FN
Poids formulaire
261.47
Point d'éclair
-17°(1°F)
Densité
0.903
Sensibilité
Hygroscopic
Solubilité
Miscible with terahydrofuran, acetonitrile, dimethyl sulfoxide and organic solvents.

Applications

Tetra-n-butylammonium fluoride, 1M soln. in THF is used as a reactant for the preparation of triple monoamine reuptake inhibitors as a new generation of antidepressants, oligoribonucleotides with phosphonate-modified linkages, conjugated dienoic acid esters using Suzuki coupling reactions and polyacetylenic glucosides. It plays an important role in aryl alkyl alcohols through Nozaki-Hiyama allylation catalyzed by chiral bipyridyldiol ligands and chromium trichloride. It is also used as a catalyst for the silylation reactions. In addition, it is used as a source of fluoride ion in organic solvents as well as for the deprotection of silyl ether groups.

Notes

Store in a cool place. Hygroscopic. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents and oxygen.

Références bibliographiques

Mild catalyst for the silylation of OH by silazanes: Tetrahedron Lett., 35, 8409 (1994), or by hydrosilanes and disilanes: Tetrahedron Lett., 35, 8413 (1994). See Appendix 4.

Specific reagent for the cleavage of silyl ethers, including TBDMS: J. Am. Chem. Soc., 94, 6190 (1972), (see tert-Butyl­dimethyl­chlorosilane, A13064), as well as the more stable TBDPS: Org. Synth. Coll., 9, 4 (1998), and TIPS: J. Org. Chem., 45, 4797 (1980); (see also tert-Butyl­diphenyl­chlorosilane, A12721 and Chlorotriisopropyl­silane, A17376).

Ester enolates can be displaced from silicon, and trapped by reaction with carbonyl compounds without ɑ-hydrogens: Tetrahedron Lett., 1699 (1976). Under similar conditions, ketones with ɑ-hydrogens are converted under kinetic control to their silyl enol ethers with high (Z)-stereoselectivity (see Ethyl­ (trimethyl­silyl)­acetate, A17707): J. Am. Chem. Soc., 98, 2346 (1976); Org. Synth. Coll., 7, 512 (1990):

For the cleavage of disilanes to give "metal-free" silyl anions, see Hexamethyl­disilane, A13155.

Promotes the directed aldol condensation of silyl enol ethers with aldehydes at low temperatures under very mild conditions: J. Org. Chem., 48, 932 (1983); alkali metal fluorides give poor results.

Reagent for deprotection of N-Boc groups under mild conditions: Tetrahedron Lett., 43, 589 (2002).

Many other examples exist where the reagent acts as a base in organic synthesis:

Acylation of hindered OH groups: Tetrahedron Lett., 1691 (1977). Nitro-aldol formation from aldehydes and nitro compounds (Henry reaction) facilitated by high pressure: Angew. Chem. Int. Ed., 23, 617 (1984). Dieckmann-type cyclization of a diester: Org. Synth. Coll., 8, 71 (1993). Catalyzes the regioselective N-alkylation of silylated purines with chloromethyl ethers: Helv. Chim. Acta, 72, 1495 (1989).

For nucleophilic displacement of halide or tosylate by TBAF in the preparation of alkyl and acyl fluorides, see: J. Org. Chem., 49, 3216 (1984); Org. Synth. Coll., 8, 258 (1993).

Reviews:

Fluoride ion as a base in organic synthesis: Chem. Rev., 80, 429 (1980). Synthetic aspects of the use of organosilicon compounds under nucleophilic catalysis conditions: Tetrahedron, 44, 2675 (1988). For a brief feature on uses of TBAF, see: Synlett, 2125 (2002).

Zhang, F.; Wu, X.; Wang, L.; Liu, H.; Zhao, Y. General and efficient one-pot synthesis of novel sugar/heterocyclic (aryl) 1, 2-diketones from sugar terminal alkynes by Sonogashira/tetra-n-butylammonium permanganate oxidation. Carbohydr. Res. 2015, 417 41-51.

Parr, B. T.; Economou, C.; Herzon, S. B. A concise synthesis of (+)-batzelladine B from simple pyrrole-based starting materials. Nature 2015, 525 (7570), 507-510.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H314-H351-H302-H335

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Suspected of causing cancer. Harmful if swallowed. May cause respiratory irritation.

Mentions de prudence: P210-P260-P201-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
3570522
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2923.90
TSCA
Yes

Recommandé

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire