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434-76-4 - 2-Amino-6-fluorobenzoic acid, 98% - 6-Fluoroanthranilic acid - A10919 - Alfa Aesar

A10919 2-Amino-6-fluorobenzoic acid, 98%

Numéro de CAS
434-76-4
Synonymes
6-Fluoroanthranilic acid

Conditionnement Prix ($) Quantité Disponibilité
1g 34,20
5g 120,00
25g 418,00
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2-Amino-6-fluorobenzoic acid, 98%

MDL
MFCD00067781
EINECS
000-000-0

Propriétés chimiques

Formule
C7H6FNO2
Poids moleculaire
155.13
Point de fusion
165-167°

Applications

Used in the synthesis of a novel benzamide with potent neuroleptic activity. 5- fluoro-2-methyl-3,l-benzoxazin-4-one was obtained from 2-amino-6-fluorobenzoic acid. The condensation of 2-amino-6-fluorobenzoic acid methyl ester and (4-fluorophenyl) acetyl chloride with N,N-dimethylamino-4-pyridine in CH 2 Cl 2 to give 2-fluoro-6-[2-(4-fluoro-phenyl)-acetylamino]-benzoic acid methyl ester in 61% yield. 2 Amino 6 fluorobenzoic acid is another easily ac cessible synthon for construction of monofluorinated heterocycles. Reactions of 2,3,4,6-tetra-O-acetyl-n-D_glucopyranosyl bromide (2) with p-hydroxybenzaldehyde, trifluoromethyl and fluoro substi- tuted aniline and 2-amino-6-fluorobenzoic acid gave lO-(Pformyl- pheny1)-2,3,4,6-tetra-O-acetyl-(3-D-glucopyranoside. 2-Fluoro-6-iodobenzoic acid,a loose white crystal,was synthesized by using 2-amino-6-fluorobenzoic acid as the starting material.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Références bibliographiques

Y.S. Shina,; S.J. Song,; S.U. Kanga,; H.S. Hwanga,; J.W. Choid,; B.H. Lee,; Y.-S. Jung,; C.-H. Kim. A novel synthetic compound, 3-amino-3-(4-fluoro-phenyl)-1H-quinoline-2,4-dione, inhibits cisplatin-induced hearing loss by the suppression of reactive oxygen species: In vitro and in vivo study. Neuroscience. 2013, 232 1-12.

Jean-Michel Becht,; Cédric Catala,;Claude Le Drian,; Alain Wagner. Synthesis of Biaryls via Decarboxylative Pd-Catalyzed Cross-Coupling Reaction . Org Letter. 2007, 9 (9), 1781-1783.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
3540926
Code tarifaire harmonisé
2922.49
TSCA
No

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Catalyseurs

Analytique et matériel de laboratoire