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18742-02-4 - 2-(2-Bromoethyl)-1,3-dioxolane, 95%, stab. with silver - 3-Bromopropanal 1,2-ethanediol acetal - 3-Bromopropionaldehyde ethylene acetal - A11441 - Alfa Aesar

A11441 2-(2-Bromoethyl)-1,3-dioxolane, 95%, stab. with silver

Numéro CAS
3-Bromopropanal 1,2-ethanediol acetal
3-Bromopropionaldehyde ethylene acetal

Dimensions Prix ($) Quantité Disponibilité
10g 38,70
50g 128,00
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2-(2-Bromoethyl)-1,3-dioxolane, 95%, stab. with silver


Propriétés chimiques

Poids formulaire
Point d'ébullition
Point d'éclair
Indice de réfraction
Light Sensitive
It is immiscible with water.


2-(2-Bromoethyl)-1,3-dioxolane is used as a pharmaceutical intermediate, dioxolanes, acetals, ketals, building blocks, chemical synthesis, organic building blocks and oxygen compounds. 1,1-(Ethylenedioxy)-3-bromopropane is used in the synthesis of EGFR inhibitors. Also used in the synthesis of orally active agents of cancer and cell proliferation with quinoline substructures. It is also used as flavouring agent.


Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Light sensitive. Store under inert gas.

Références bibliographiques

George Buechi.; Hans Wuest. Synthesis of (+-)-nuciferal. J. Org. Chem.196934, (4), 1122-1123.

Ehud Keinan.; Zeev Roth. Regioselectivity in organo-transition-metal chemistry. A new indicator substrate for classification of nucleophiles. J. Org. Chem.198348, (10), 1769-1772.

Masked ß-formylethyl synthon, compare preceding entry. The derived Grignard, which, unlike the dioxane analogue, is unstable above room temperature, shows similar attenuated reactivity in comparison with simple alkyl Grignard reagents, reacting with acid chlorides to give -ketoaldehydes without carbinol formation, and with enones to give, at low temperatures, predominantly the 1,4-addition product without the need for Cu catalysis:Tetrahedron Lett., 28, 3217 (1987).

The Grignard undergoes coupling reactions (CuBr2 + LiCl catalysis) with allylic halides: Tetrahedron Lett., 4549 (1979); J. Org. Chem., 46, 1504 (1981), allylic acetates: J. Am. Chem. Soc., 104, 2269 (1982), and primary alkyl bromides: J. Org. Chem., 48, 1767 (1983).

For a review of 3-carbon homologating reagents, including many examples of Grignard and organocuprate reactions of these molecules, see: Chem. Rev., 84, 409 (1984).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H301-H315-H319-H335-H227

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Mentions de prudence: P210-P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Classe de danger
Groupe d'emballage
Code tarifaire harmonisé


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