A11469 6-Fluoro-2-methylquinoline, 98+%
FDS
| Stock No. | Conditionnement | Prix ($) | Quantité | Disponibilité |
|---|---|---|---|---|
| A11469-06 | 5g | 71,80 |
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| A11469-14 | 25g | 268,00 |
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| A11469-22 | 100g | 992,00 |
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6-Fluoro-2-methylquinoline, 98+%
Propriétés chimiques
Applications
Metal-free transfer hydrogenation of 6-fluoro-2-methylquinoline by employing several chiral Brønsted acid catalysts was carried out in combination with dihydropyridines as the hydride source in asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Hydrogenation product of 6-fluoro-2-methylquinoline is the key intermediate of the antibacterial agent.
Notes
Références bibliographiques
Magnus Rueping,; Mirjam Stoeckel,; Erli Sugiono,; Thomas Theissmann. Asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Tetrahedron. 2010 , 6633,6565-6568.
Nadia M. Ahmad,; Jie Jack Li. Palladium in Quinoline Synthesis. Advances in Heterocyclic Chemistry. 2003, 841-30.
Mentions de danger et de prudence du SGH
Mentions de danger (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
