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105-56-6 - Ethyl cyanoacetate, 98+% - Cyanoacetic acid ethyl ester - A11498 - Alfa Aesar

A11498 Ethyl cyanoacetate, 98+%

Numéro de CAS
105-56-6
Synonymes
Cyanoacetic acid ethyl ester

Conditionnement Prix ($) Quantité Disponibilité
500g 43,20
2500g 169,00
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Ethyl cyanoacetate, 98+%

MDL
MFCD00001940
EINECS
203-309-0

Propriétés chimiques

Formule
C5H7NO2
Poids moleculaire
113.12
Point de fusion
-23°
Point d'ébullition
208-210°
Point d'éclair
109°(228°F)
Densité
1.063
Indice de réfraction
1.4180
Solubilité
It is slightly soluble in water. Mostly soluble in organic solvents such as chloroform, ethyl acetate.

Applications

Cyanoacetate is a building block for the synthesis of heterocycles and are are used as drugs. It is also used as Pharmaceutical intermediates, or Oil soluble couplers of film raw material . It is also used as a reagent in labelled pyrimidine and purine synthesis. It is used as an intermediate of fine chemicals such as medicine and dyestuff.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials strong acids, strong bases, strong oxidizing agents, strong reducing agents.

Références bibliographiques

Jose A. Cabello.; Juan M. Campelo.; Angel Garcia.; Diego Luna.; Jose M. Marinas. Knoevenagel condensation in the heterogeneous phase using aluminum phosphate-aluminum oxide as a new catalyst. J. Org. Chem. 1984, 49, (26), 5195-5197.

Rajendra K. Singh.; Samuel Danishefsky. Preparation of activated cyclopropanes by phase transfer alkylation. J. Org. Chem. 1975, 40, (20), 2969-2970.

Stereoselective alkylation of the active methylene has been accomplished under particularly mild conditions with secondary alkyl mesylates in the presence of CsF in DMF; complete inversion occurs at the secondary alkyl carbon: J. Org. Chem., 60, 2627 (1995).

Arylation by aryl iodides is promoted by copper(I) iodide: Synthesis, 67 (1983); J. Org. Chem., 58, 7606 (1993); or trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491: Synthesis, 506 (1985).

For examples of Knoevenagel condensations of cyanoacetic esters with carbonyl compounds, see: Org. Synth. Coll., 3, 385, 399 (1955); 4, 93, 463 (1963); review: Org. React., 15, 204 (1967). Knoevenagel condensation with aromatic aldehydes has also been carried out under acidic conditions, for example, good yields have been obtained with ZnCl2: Tetrahedron Lett., 32, 5821 (1991).

For use in the synthesis of pyrrole derivatives, see p-Toluenesulfonyl­methyl­ isocyanide, A14312.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,3786
Beilstein
605871
Code tarifaire harmonisé
2926.90
TSCA
Yes
RTECS
AG4110000

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