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383-63-1 - Ethyl trifluoroacetate, 99% - Trifluoroacetic acid ethyl ester - A11520 - Alfa Aesar

A11520 Ethyl trifluoroacetate, 99%

Numéro CAS
383-63-1
Synonymes
Trifluoroacetic acid ethyl ester

Dimensions Prix ($) Quantité Disponibilité
50g 41,60
250g 183,00
1000g 663,00
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Ethyl trifluoroacetate, 99%

MDL
MFCD00000419
EINECS
206-851-6

Propriétés chimiques

Formule
C4H5F3O2
Poids formulaire
142.08
Point de fusion
<-78°
Point d'ébullition
60-62°
Point d'éclair
-1°(30°F)
Densité
1.192
Indice de réfraction
1.3070
Sensibilité
Moisture Sensitive
Solubilité
Slightly miscible with water. Miscible with chloroform and methanol.

Applications

Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.

Notes

Moisture Sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents, strong bases and strong acids.

Références bibliographiques

Reagent for selective trifluoroacetylation of amines. Primary amines can be protected in the presence of secondary, and diamines selectively monoprotected. Primary amines can also be differentiated in terms of steric hindrance: Tetrahedron Lett., 36, 7357 (1995).

Esters of perfluoroalkyl carboxylic acids undergo Wittig reactions, for example with the ylide from (3-Phenyl­propyl)­triphenyl­phosphonium bromide, A12669, leading to 1-perfluoroalkyl enol ethers, which are useful precursors of various fluorinated derivatives: J. Org. Chem., 57, 3807 (1992); Org. Synth., 75, 153 (1997):

Bhattacharjee, D.; Tiwari, L.; Singh, H. J.; Mishra, B. K.; Deka, R. C. Theoretical investigation on mechanism, kinetics and thermochemistry of gas-phase reactions of ethyl trifluoroacetate with OH radicals. J. Fluorine Chem. 2015, 178, 79-85.

Huang, Z.; Jiang, H.; Li, L.; Wang, H.; Qiu, T. Density, viscosity, and saturated vapor pressure of ethyl trifluoroacetate. J. Chem. Thermodyn. 2015, 86, 75-79.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1761411
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2915.90
TSCA
Yes

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Analytique et matériel de laboratoire