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506-59-2 - Dimethylamine hydrochloride, 98+% - Dimethylammonium chloride - A12133 - Alfa Aesar

A12133 Dimethylamine hydrochloride, 98+%

Numéro de CAS
506-59-2
Synonymes
Dimethylammonium chloride

Conditionnement Prix ($) Quantité Disponibilité
250g 22,60
1000g 62,90
5000g 263,00
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Dimethylamine hydrochloride, 98+%

MDL
MFCD00012477
EINECS
208-046-5

Propriétés chimiques

Formule
(CH3)2NH•HCl
Poids moleculaire
81.55
Point de fusion
168-174°
Sensibilité
Hygroscopic
Solubilité
Soluble in water, alcohol and chloroform

Applications

Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.

Notes

Hygroscopic. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agent.

Références bibliographiques

Chloride source giving a high degree of stereoselectivity in the ring opening of epoxy alcohols mediated by Titanium(IV)­ isopropoxide, A13703: Chem. Lett., 357 (1989).

The Willgerodt reaction can be carried out at steam-bath temperature by the use of dimethylamine hydrochloride and sodium acetate in DMF in place of Morpholine, A10355: Synthesis, 730 (1983).

Reductive amination of aldehydes and ketones occurs with titanium isopropoxide followed by sodium borohydride, giving a convenient route to N,N-dimethylated tertiary amines: J. Org. Chem., 60, 4928 (1995).

Nortcliffe, A.; Moody, C. J. Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry. Bioorg Med Chem 2015, 23 (11), 2730-2735.

Lan, J. S.; Pan, L. F.; Xie, S. S.; Wang, X. B.; Kong, L. Y. Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors. Med. Chem. Commun. 2015, 6 (4), 592-600.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,3228
Beilstein
3589311
Code tarifaire harmonisé
2921.11
TSCA
Yes
RTECS
IQ0220000

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