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70-55-3 - p-Toluenesulfonamide, 98+% - 4-Methylbenzenesulfonamide - Toluene-4-sulfonamide - A12156 - Alfa Aesar

A12156 p-Toluenesulfonamide, 98+%

Numéro de CAS
70-55-3
Synonymes
4-Methylbenzenesulfonamide
Toluene-4-sulfonamide

Conditionnement Prix ($) Quantité Disponibilité
250g 22,20
500g 39,00
2500g 131,00
10000g 395,00
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p-Toluenesulfonamide, 98+%

MDL
MFCD00011692
EINECS
200-741-1

Propriétés chimiques

Formule
C7H9NO2S
Poids moleculaire
171.22
Point de fusion
136-139°
Point d'ébullition
221°/10mm
Point d'éclair
202°(395°F)
Solubilité
Soluble in water.

Applications

p-Toluene sulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. It act as a derivative of ammonia activated to alkylation by alkyl halides is exemplified by the synthesis of N-tosyl-2,3-dihydroisoindole from o-xylylene dibromide. It is a precursor of N-tosyl imines.

Notes

Store in cool, dry place, in well sealed container. Store away from oxidizing agents.

Références bibliographiques

Kui Lu; Ohyun Kwon. Phosphine-Catalyzed [4+2] Annulation: Synthesis of Ethyl 6-Phenyl-1-Tosyl-1,2,5,6-Tetrahydropyridine-3-Carboxylate. Organic Syntheses. 2009, 2009 (86), 212-224.

D. S. Tarbell; Clay Weaver. The Condensation of Sulfoxides with p-Toluenesulfonamide and Substituted Acetamides. J. Am. Chem. Soc. 1941, 63 (11), 2939-2942.

Use of p-toluenesulfonamide as a derivative of ammonia activated to alkylation by alkyl halides is exemplified by the synthesis of N-tosyl-2,3-dihydroisoindole from o-xylylene dibromide: Org. Synth. Coll., 5, 1064 (1973). Similarly, has been used as the precursor of nitrogen-containing crown ethers; see, e.g.: J. Org. Chem., 53, 5292 (1988).

Precursor of N-tosyl imines, which are useful intermediates in synthesis: Synlett, 2097 (2003).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
472689
Code tarifaire harmonisé
2935.90
TSCA
Yes
RTECS
XT5075000

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Catalyseurs

Analytique et matériel de laboratoire