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76-05-1 - Trifluoroacetic acid, 99% - Perfluoroacetic acid - A12198 - Alfa Aesar

A12198 Trifluoroacetic acid, 99%

Numéro CAS
76-05-1
Synonymes
Perfluoroacetic acid

Dimensions Prix ($) Quantité Disponibilité
100g 37,19
500g 115,15
2500g 452,17
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Trifluoroacetic acid, 99%

MDL
MFCD00004169
EINECS
200-929-3

Propriétés chimiques

Formule
CF3CO2H
Poids formulaire
114.02
Point de fusion
-15°
Point d'ébullition
72-73°
Densité
1.480
Indice de réfraction
1.2840
Sensibilité
Hygroscopic
Solubilité
Miscible with ether, acetone, ethanol, benzene, hexane, and CCl<sub>4</sub>

Applications

The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

Notes

Trifluoroacetic acid (TFA) is a stable, hygroscopic, volatile and low-boiling organic acid. Storage in a cool place is recommended.

Références bibliographiques

López, S. E.; Salazar, J. Trifluoroacetic acid: Uses and recent applications in organic synthesis. J. Fluorine Chem. 2013, 156, 73-100.

Natu, A. D.; Burde, A. S.; Limaye, R. A.; Paradkar, M. V. Acceleration of the Dakin reaction by trifluoroacetic acid. J. Chem. Res. 2014, 38 (6), 325-386.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H332-H412

Causes severe skin burns and eye damage. Harmful if inhaled. Harmful to aquatic life with long lasting effects.

Mentions de prudence: P260-P261-P273-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,9681
Beilstein
742035
Classe de danger
8
Groupe d'emballage
I
Code tarifaire harmonisé
2915.90
TSCA
Yes
RTECS
AJ9625000

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Analytique et matériel de laboratoire