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300-87-8 - 3,5-Dimethylisoxazole, 99% - A12217 - Alfa Aesar

A12217 3,5-Dimethylisoxazole, 99%

Numéro CAS
300-87-8
Synonymes

Dimensions Prix ($) Quantité Disponibilité
25g 38,16
100g 133,90
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3,5-Dimethylisoxazole, 99%

MDL
MFCD00003156
EINECS
206-100-2

Propriétés chimiques

Formule
C5H7NO
Poids formulaire
97.12
Point de fusion
-14°
Point d'ébullition
142-144°
Point d'éclair
31°(87°F)
Densité
0.992
Indice de réfraction
1.4415
Solubilité
Insoluble in water.

Applications

The optimization of 3,5-dimethylisoxazole derivatives to develop potent inhibitors of the BET (bromodomain and extra terminal domain) bromodomain family with good ligand efficiency. It has hypoglycemic activity.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Références bibliographiques

Hewings DS; Fedorov O; Filippakopoulos P.; Martin S.; Picaud S.; Tumber A.; Wells C.; Olcina MM.; Freeman K.; Gill A.; Ritchie AJ.; Sheppard DW.; Russell AJ.; Hammond EM; Knapp S; Brennan PE; Conway SJ.Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem. 2013, 56 (8), 3217-27.

William E. Dulin; George C. Gerritsen. Hypoglycemic Activity of 3,5 Dimethylisoxazole. Exp Biol Med. 1963, 113 (3), 683-685.

Lithiation occurs first at the 5-methyl group. Subsequent reaction with electrophiles can be followed by further lithiation of the 3-methyl, providing a route to substituted isoxazoles, and also to 1,3-diketones by acid hydrolysis or ß-aminoketones by hydrogenolysis: Tetrahedron Lett., 22, 3699 (1981):

Review: Reaction of 3,5-dimethylisoxazole with some electrophiles: Heterocycles, 6, 805 (1977).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H226

Flammable liquid and vapour.

Mentions de prudence: P210-P280-P240-P241-P233-P242-P243-P303+P361+P353-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Keep container tightly closed. Use only non-sparking tools. Take precautionary measures against static discharge. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
106324
Classe de danger
3
Groupe d'emballage
III
Code tarifaire harmonisé
2934.99
TSCA
Yes
RTECS
NY2774200

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