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504-24-5 - 4-Aminopyridine, 98% - Fampridine - 4-Pyridinamine - A12405 - Alfa Aesar

A12405 4-Aminopyridine, 98%

Numéro CAS
504-24-5
Synonymes
Fampridine
4-Pyridinamine

Dimensions Prix ($) Quantité Disponibilité
50g 53,25
250g 186,10
1000g 566,40
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4-Aminopyridine, 98%

MDL
MFCD00006439
EINECS
207-987-9

Propriétés chimiques

Formule
C5H6N2
Poids formulaire
94.12
Point de fusion
157-161°
Point d'ébullition
273-274°
Point d'éclair
164°(327°F)
Densité
1.26
Solubilité
Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.

Applications

It is used as a research tool, in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis. In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. Spinal cord injury patients have also seen improvement with 4-AP therapy.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Références bibliographiques

H Bostock et. al.The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres. Journal of Physiology. 1981, 313 301-315.

Shun-ichi Yamaguchi,; Michael A. Rogawski.Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice . Epilepsy Research. 1992, 11(1), 9-16.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H300-H311-H315-H319-H335-H411-H401

Fatal if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Toxic to aquatic life with long lasting effects. Toxic to aquatic life.

Mentions de prudence: P273-P280h-P270-P301+P310-P305+P351+P338-P302+P352

Avoid release to the environment. Wear protective gloves/clothing. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF ON SKIN: Wash with plenty of soap and water.

Autres références

Merck
14,3933
Beilstein
105782
Classe de danger
6.1
Groupe d'emballage
II
Code tarifaire harmonisé
2933.39
TSCA
Yes
RTECS
US1750000

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Catalyseurs

Analytique et matériel de laboratoire