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107-91-5 - Cyanoacetamide, 99% - Malonamide nitrile - A12482 - Alfa Aesar

A12482 Cyanoacetamide, 99%

Numéro CAS
107-91-5
Synonymes
Malonamide nitrile

Dimensions Prix ($) Quantité Disponibilité
100g 21,84
500g 71,19
2500g 260,10
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Cyanoacetamide, 99%

MDL
MFCD00008024
EINECS
203-531-8

Propriétés chimiques

Formule
NCCH2CONH2
Poids formulaire
84.08
Point de fusion
118-122°
Point d'éclair
215°(419°F)
Solubilité
Soluble in water.

Applications

Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum. Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes.

Notes

Store under cool dry place. Ensure good ventilation. Incompatible with oxidizing agents.

Références bibliographiques

Fadda AA, et al..; Turk. J. Cyanoacetamide derivatives as synthons in heterocyclic synthesis. J. Chem. 2008, 32 (3),259-286.

Honda S, et al. Fluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexes. Anal. Chem. 1980, 52 (7), 1079-1082.

Review of utility in heterocyclic synthesis: Heterocycles, 24, 2023 (1986). Reaction with various enones and enals in the presence of KO-t-Bu and oxygen in DMSO provides a one-step route to functionalized 3-cyano-2-pyridones: Tetrahedron Lett., 36, 3307 (1995):

In the absence of oxygen, only Michael addition occurs.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,2688
Beilstein
878221
Code tarifaire harmonisé
2926.90
TSCA
Yes
RTECS
AB5950000

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