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345909-35-5 - 4-Hydroxyquinoline-2-carboxylic acid hydrate, 98% - Kynurenic acid - A12602 - Alfa Aesar

A12602 4-Hydroxyquinoline-2-carboxylic acid hydrate, 98%

Numéro CAS
345909-35-5
Synonymes
Kynurenic acid

Dimensions Prix ($) Quantité Disponibilité
1g 19,28
5g 81,58
25g 354,32
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4-Hydroxyquinoline-2-carboxylic acid hydrate, 98%

MDL
MFCD00006753
EINECS
207-751-5

Propriétés chimiques

Formule
C10H7NO3•xH2O
Poids formulaire
189.17(anhy)
Point de fusion
ca 275° dec.
Solubilité
Soluble in hot ethanol and water. Insoluble in ether. 

Applications

Broad spectrum excitatory amino acid antagonist4-Hydroxyquinoline-2-carboxylic acid hydrate is used as an intermediate in synthetic chemistry. It acts as an antiexcitotoxic and anticonvulsant. It finds application in certain neurobiological disorders therapy.

Notes

Incompatible with oxidizing agents.

Références bibliographiques

Pesek, J.; Svoboda, J.; Sattler, M.; Bartram, S.; Boland, W. Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis. Org. Biomol. Chem. 2015, 13 (1), 178-184.

Tajti, J.; Majlath, Z.; Szok, D.; Csati, A.; Toldi, J.; Fulop, F.; Vecsei, L. Novel Kynurenic Acid Analogues in the Treatment of Migraine and Neurodegenerative Disorders: Preclinical Studies and Pharmaceutical Design. Curr. Pharm. Des. 2015, 21 (17), 2250-2258.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,5327
Beilstein
147451
Code tarifaire harmonisé
2933.49
TSCA
No
RTECS
VB2080000

Recommandé

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    L-Citrulline, 98%
  • L12760

    2-Amino-4-hydroxyquinoline hydrate, 97%, water ca 10%
  • L15827

    12-Molybdophosphoric acid hydrate, Mo >47.5%

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire