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541-16-2 - Di-tert-butyl malonate, 98+%, stab. with potassium carbonate - Malonic acid di-tert-butyl ester - A12774 - Alfa Aesar

A12774 Di-tert-butyl malonate, 98+%, stab. with potassium carbonate

Numéro CAS
541-16-2
Synonymes
Malonic acid di-tert-butyl ester

Dimensions Prix ($) Quantité Disponibilité
10g 52,65
50g 201,60
250g 703,20
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Di-tert-butyl malonate, 98+%, stab. with potassium carbonate

MDL
MFCD00008810
EINECS
208-769-6

Propriétés chimiques

Formule
C11H20O4
Poids formulaire
216.28
Point de fusion
-6°
Point d'ébullition
65-67°/1mm
Point d'éclair
88°(190°F)
Densité
0.965
Indice de réfraction
1.4190
Solubilité
It is hardly soluble in water.

Applications

Di-tert-butyl malonate, is used as a pharmaceutical intermediate. it can be used to produce Diazomalonsaeure-di-tert-butylester at the ambient temperature. It will need reagents cesium carbonate, p-toluenesulfonyl azide and solvent tetrahydrofuran with the reaction time of 1 hour. T

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents, strong bases.

Références bibliographiques

AL McCloskey.; GS Fonken.; RW Kluiber. Di-tert-butyl Malonate. organic chemistry. 200373, (1) , 49-57.

DY Kim.;SC Huh.; SM Kim. Enantioselective Michael reaction of malonates and chalcones by phase-transfer catalysis using chiral quaternary ammonium salt. Tetrahedron Letters. 200142, (36) , 6299-6301.

Alternative to Diethyl­ malonate, A15468, permitting removal of the t-butyl groups and decarboxylation by thermolysis in the presence of mild acid: J. Am. Chem. Soc., 74, 831 (1952). In the presence of Cu(OAc)2, condenses with paraformaldehyde to form the useful electrophilic alkene, di-t-butyl methylenemalonate: J. Org. Chem., 48, 3603 (1983), which is more stable than the ethyl or methyl esters, and can be stored for some weeks at room temperature. For references to use of methylenemalonic esters in Michael addition and cycloaddition reactions, see: Org. Synth. Coll., 7, 142 (1990).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H317-H227

May cause an allergic skin reaction. Combustible liquid.

Mentions de prudence: P210-P261-P280-P363-P321-P333+P313-P302+P352-P370+P378a-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Wash contaminated clothing before reuse. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. IF ON SKIN: Wash with plenty of soap and water. In case of fire: Use for extinction: CO2, powder or water spray. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,3034
Beilstein
1781766
Code tarifaire harmonisé
2917.19
TSCA
Yes

Recommandé

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Catalyseurs

Analytique et matériel de laboratoire