Consentement d'utilisation des Cookies

J'accepte. Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

1066-54-2 - (Trimethylsilyl)acetylene, 98% - Ethynyltrimethylsilane - TMS acetylene - A12856 - Alfa Aesar

A12856 (Trimethylsilyl)acetylene, 98%

Numéro de CAS
TMS acetylene

Conditionnement Prix ($) Quantité Disponibilité
5g 36,70
25g 157,00
100g 408,00
Ajouter au panier Ajouter au devis en vrac Afficher l'article

(Trimethylsilyl)acetylene, 98%


Propriétés chimiques

Poids moleculaire
Point d'ébullition
Point d'éclair
Indice de réfraction
Miscible with organic solvents.


(Trimethylsilyl)acetylene is used in the preparation of trimethylsilanyl-propiolic acid ethyl ester by reacting with carbonochloridic acid ethyl ester as well as in the synthesis of iodoalkenes by radical addition of perfluoroalkyl iodides. It is used as a nucleophile in Friedel-Crafts type acylations and alkylations reactions, as a ligand in organometallic chemistry and an useful reagent in cycloaddition reactions. It acts as a precursor to lithium trimethylsilylacetylide It finds application in the synthesis of (±)-estrone.


Store in a cool place. Incompatible with strong oxidizing agents.

Références bibliographiques

Pd catalyzed coupling with aryl bromides or iodides gives aryl TMS alkynes, from which the TMS group is readily cleaved by K2CO3 in MeOH: Synthesis, 627 (1980); J. Org. Chem., 46, 2280 (1981). Coupling with 1-bromo-2-nitrobenzene or ethyl 2-bromocarbanilate gives indole precursors. Other terminal alkynes lead to 2-substituted indoles: Heterocycles, 24, 31 (1986):

Cross-coupling with aryl halides can also be catalyzed by Pd-C in the presence of Ph3P, CuI and Et3N: Synth. Commun., 20, 2059 (1990); for an example, see 2-Bromonaphthalene, A15300. Pd catalyzed coupling with quinolinol and isoquinolinol triflates has also been reported: Tetrahedron, 51, 3737 (1995). For coupling with vinyl halides catalyzed by Tetrakis(triphenyl­phosphine)­palladium(0)­, 10548 in the presence of CuI as an example of a route to enynes, see: Tetrahedron Lett., 30, 6997 (1989); Org. Synth. Coll., 9, 117 (1998). CuCl-TMEDA catalyzed oxidative (Hay) coupling gives bis(TMS)-1,3-butadiyne: Org. Synth. Coll., 8, 63 (1993).

For the synthesis of iodoalkenes by radical addition of perfluoroalkyl iodides, see: J. Org. Chem., 47, 2251 (1982).

Das, S.; Samanta, S.; Ray, S.; Biswas, P. 3, 6-Di (pyridin-2-yl)-1, 2, 4, 5-tetrazine capped Pd (0) nanoparticles: a catalyst for copper-free Sonogashira coupling of aryl halides in aqueous medium. J. Chromatogr. A 2015, 1379, 56-64.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225

Highly flammable liquid and vapour.

Mentions de prudence: P210-P280a-P240-P241-P303+P361+P353-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Classe de danger
Groupe d'emballage
Code tarifaire harmonisé


  • A12139

    Phenylacetylene, 98+%
  • A15275

    Boron trifluoride diethyl etherate, 98+%
  • A17020

    1-Bromo-2-iodobenzene, 98+%, stab. with copper
  • 10491

    trans-Dichlorobis(triphenylphosphine)palladium(II), Pd 14.0% min
  • 43153

    Copper(I) iodide, Puratronic®, 99.998% (metals basis)

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux


Analytique et matériel de laboratoire