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626-55-1 - 3-Bromopyridine, 98+% - A12894 - Alfa Aesar

A12894 3-Bromopyridine, 98+%

Numéro CAS
626-55-1
Synonymes

Dimensions Prix ($) Quantité Disponibilité
25g 41,49
100g 104,31
500g 465,60
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3-Bromopyridine, 98+%

MDL
MFCD00006373
EINECS
210-952-0

Propriétés chimiques

Formule
C5H4BrN
Poids formulaire
158.00
Point de fusion
-27°
Point d'ébullition
172-174°
Point d'éclair
83°(181°F)
Densité
1.617
Indice de réfraction
1.5700
Solubilité
Soluble in water (31 g/L at 20°C).

Applications

3-Bromopyridine undergoes lithiation with LDA at low temperatures in the 4-position: Heterocycles, involved in formation of the Grignard by Mg exchange with i-PrMgCl and in transmetallation of the lithiated derivative with zinc chloride followed by treatment with an electrophile as a route to 4-substituted 3-bromopyridines.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with strong acids.

Références bibliographiques

Jennifer A. Love Dr.; John P. Morgan.;Tina M. Trnka.;Robert H. Grubbs Prof. A Practical and Highly Active Ruthenium-Based Catalyst that Effects the Cross Metathesis of Acrylonitrile. Angewandte Chemie International Edition. 2002, 41 (21), 4035-4037.

Wenjie Li.; Dorian P. Nelson.; Mark S. Jensen.; R. Scott Hoerrner.; Dongwei Cai.; Robert D. Larsen.; Paul J. Reider. An Improved Protocol for the Preparation of 3-Pyridyl- and Some Arylboronic Acids. J. Org. Chem. 2002, 57 (16), 5394-5397.

Undergoes lithiation with LDA at low temperatures in the 4-position: Heterocycles, 35, 151 (1993). Formation of the Grignard by Mg exchange with i-PrMgCl: Tetrahdron Lett., 40, 4339 (1999). Transmetallation of the lithiated derivative with ZnCl2 followed by treatment with an electrophile has been described, as a route to 4-substituted 3-bromopyridines: Org. Lett., 3, 835 (2001).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H311-H302-H332-H315-H319-H335-H227

Toxic in contact with skin. Harmful if swallowed. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Mentions de prudence: P280h-P305+P351+P338-P309-P310

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Autres références

Beilstein
105880
Classe de danger
6.1
Groupe d'emballage
III
Code tarifaire harmonisé
2933.39
TSCA
Yes

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Catalyseurs

Analytique et matériel de laboratoire