Bromoacetaldehyde diethyl acetal, is used as a synthetic building block. It is mainly used for synthesis of antibiotics such as erythromycin and cephalosporins and to other drugs. It also can be used as pharmaceutical intermediates. Besides, this chemical can be used to pruduce drugs such as methylthio imidazole, chlorpheniramine and others for thyroid. It also acts as a Useful intermediate for the preparation of other ?-heterosubstituted acetaldehyde acetals.
G Lu.; YM Li.; XS Li.; ASC Chan. Synthesis and application of new chiral catalysts for asymmetric alkynylation reactions. journal of molecular evolution.1997, 44,(3), 237 -241.
WP McCann.; LM Hall.; WK Nonidez. Preparation, titration, and storage of chloroacetaldehyde for fluorometric determination of adenine and its derivatives. Analytical Chemistry.1983, 55,(8), 1454-1455.
Useful intermediate for the preparation of other ɑ-heterosubstituted acetaldehyde acetals, e.g. the corresponding thiol by reaction with sodium polysulfide and reductive cleavage with Na in liquid ammonia: Org. Synth. Coll., 4, 295 (1963).
Precursor of the easily-polymerized ketene diethyl acetal, by dehydrobromination with KO-t-Bu: Org. Synth. Coll., 3, 506 (1965).
Mentions de danger (UE): H227-H301-H330-H315-H319-H335
Combustible liquid. Toxic if swallowed. Fatal if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Mentions de prudence: P260-P201-P280a-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.