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51-21-8 - 5-Fluorouracil, 99% - 5-Fluoro-2,4(1H,3H)-pyrimidinedione - 5-FU - A13456 - Alfa Aesar

A13456 5-Fluorouracil, 99%

Numéro CAS
51-21-8
Synonymes
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-FU

Dimensions Prix ($) Quantité Disponibilité
5g 69,10
25g 280,00
100g 944,00
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5-Fluorouracil, 99%

MDL
MFCD00006018
EINECS
200-085-6

Propriétés chimiques

Formule
C4H3FN2O2
Poids formulaire
130.08
Point de fusion
ca 282° dec.
Sensibilité
Light Sensitive
Solubilité
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.

Applications

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

Notes

Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Références bibliographiques

Antineoplastic agent. Not for drug use.

Cosco, D.; Paolino, D.; Maiuolo, J.; Di Marzio, L.; Carafa, M.; Ventura, C. A.; Fresta, M. Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. Int. J. Pharm. 2015, 489 (1-2), 1-10.

Wu, X.; He, C.; Wu, Y.; Chen, X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials 2016, 75, 148-162.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H360-H341-H373-H302

May damage fertility or the unborn child. Suspected of causing genetic defects. May cause damage to organs through prolonged or repeated exposure. Harmful if swallowed.

Mentions de prudence: P260-P201-P281-P264-P270-P301+P312-P308+P313-P314-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Get medical advice/attention if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,4181
Beilstein
127172
Classe de danger
6.1
Groupe d'emballage
III
Code tarifaire harmonisé
2933.59
TSCA
Yes
RTECS
YR0350000

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Catalyseurs

Analytique et matériel de laboratoire