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6940-76-7 - 1-Chloro-3-iodopropane, 98%, stab. with copper - Trimethylene chloroiodide - A13489 - Alfa Aesar

A13489 1-Chloro-3-iodopropane, 98%, stab. with copper

Numéro CAS
6940-76-7
Synonymes
Trimethylene chloroiodide

1-Chloro-3-iodopropane, 98%, stab. with copper

MDL
MFCD00001096
EINECS
230-088-8

Propriétés chimiques

Formule
ClCH2CH2CH2I
Poids formulaire
204.44
Point d'ébullition
170-172°
Point d'éclair
>110°(230°F)
Densité
1.904
Indice de réfraction
1.5463
Sensibilité
Light Sensitive
Solubilité
Difficult to mix.

Applications

1-Chloro-3-iodopropane has been used in the synthesis of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid, an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase), interesting proton sponge type molecule quino[7,8-h]quinoline.

Notes

Light Sensitive. Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Références bibliographiques

Jen-Yen Cheng.; Yen-Ho Chu. 1-Butyl-2,3-trimethyleneimidazolium bis(trifluoromethylsulfonyl)imide ([b-3C-im][NTf2]): a new, stable ionic liquid. Tetrahedron Letters. 2006, 47, (10), 1575-1579.

T. B. Scoggins.; J. M. White. The Thermal Chemistry of 1-Chloro-3-Iodopropane (ClC3H6I) Adsorbed on Pt(111). J. Phys. Chem. B. 1999, 103, (44), 9663-9672.

Bifunctional alkylating agent in which the two halogens may be displaced successively with different nucleophiles. For use in the alkylation of diphenyl sulfide and cyclization to the cyclopropyl diphenyl sulfonium salt, see: Org. Synth. Coll., 6, 364 (1988).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1731115
Code tarifaire harmonisé
2903.79
TSCA
Yes

Recommandé

Consulté récemment

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Catalyseurs

Analytique et matériel de laboratoire