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21169-71-1 - Isoxazole-5-carboxylic acid, 98% - A13739 - Alfa Aesar

A13739 Isoxazole-5-carboxylic acid, 98%

Numéro CAS
21169-71-1
Synonymes

Dimensions Prix ($) Quantité Disponibilité
1g 66,90
5g 249,00
25g 1055,00
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Isoxazole-5-carboxylic acid, 98%

MDL
MFCD00156151

Propriétés chimiques

Formule
C4H3NO3
Poids formulaire
113.07
Point de fusion
141-144°
Sensibilité
Moisture Sensitive
Solubilité
Slightly soluble in water.

Applications

Reaction conditions were found to allow the exclusive formation of isoxazole-5-carboxylic acid derivatives by conjugate addition, in acidic medium, of hydroxylamine to β-alkoxyvinyl trichloromethyl ketone in synthesis and reactivity of isoxazoles. Isoxazole-5-carboxylic acid participates in the Synthesis and evaluation of acylguanidine FXa inhibitors. 1, 1, 1-trichloro-4-methoxy-3-penten-2-one postulated in the preparation of isoxazole-5-carboxylic acid from trichloroacetyl chloride, ethyl vinyl ether and hydroxylamine is developed in a fully saturated nitrogen atom theerefore there is no possibility of conjugation with 4- substituents.

Notes

Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, reducing agents, bases.

Références bibliographiques

Pinho e Melo,; Teresa M.V.D. Recent Advances on the Synthesis and Reactivity of Isoxazoles. Current Organic Chemistry. 2005, 9(10), 925-958(34)

Martins, Marcos A. P.; Cunico, Wilson; Pereira, Claudio M. P.; Sinhorin, Adilson P.; Flores, Alex F. C.; Bonacorso, Helio G.; Zanatta, Nilo. 4-Alkoxy-1,1,1-Trichloro-3-Alken-2-ones: Preparation and Applications in Heterocyclic Synthesis . Current Organic Chemistry. 2004, 1(4), 391-403(13).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé
2934.99
TSCA
No

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