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5394-63-8 - 2,2,6-Trimethyl-1,3-dioxin-4-one, 94%, cont. up to ca 6% acetone - Diketene acetone adduct - 2,2,6-Trimethyl-1,3-dioxolenone - A14254 - Alfa Aesar

A14254 2,2,6-Trimethyl-1,3-dioxin-4-one, 94%, cont. up to ca 6% acetone

Numéro CAS
5394-63-8
Synonymes
Diketene acetone adduct
2,2,6-Trimethyl-1,3-dioxolenone

Dimensions Prix ($) Quantité Disponibilité
25g 24,82
100g 74,57
500g 232,80
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2,2,6-Trimethyl-1,3-dioxin-4-one, 94%, cont. up to ca 6% acetone

MDL
MFCD00040468
EINECS
226-403-3

Propriétés chimiques

Formule
C7H10O3
Poids formulaire
142.15
Point de fusion
Point d'ébullition
65-67°/2mm
Point d'éclair
14°(57°F)
Densité
1.094
Indice de réfraction
1.4610
Solubilité
Soluble in Chloroform, Methanol. Not miscible in water.

Applications

2,2,6-Trimethyl-1,3-dioxin-4-one is used in the synthesis of dihydropyrimininones as picomolar sodium iodide symporter inhibitors. It is also used in the synthesis of resorcinol amide Hsp90 Inhibitor AT13387. It is used in the synthesis of acetylketene by flash pyrolysis.

Notes

Store at 4°C. Protect from heat. Store away from oxidizing agents.

Références bibliographiques

David M. Birney; Xiaolian Xu; Sihyun Ham and Xiaomeng Huang. Chemoselectivity in the Reactions of Acetylketene and Acetimidoylketene:? Confirmation of Theoretical Predictions. J. Org. Chem.1997, 62 (21), 7114-7120.

Convenient alternative to diketene in many reactions, stable in the absence of base: J. Am. Chem. Soc., 75, 5400 (1953).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H315-H319-H335

Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
2408
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2912.50
TSCA
No

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