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A14715 2-Iodoacetamide, 98%, stab. with ca 5-8% water

Numéro de CAS
144-48-9
Synonymes

Stock No. Conditionnement Prix ($) Quantité Disponibilité
A14715-06 5g 22,20
A14715-14 25g 65,80
A14715-22 100g 215,00
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2-Iodoacetamide, 98%, stab. with ca 5-8% water

MDL
MFCD00008028
EINECS
205-630-1

Propriétés chimiques

Formule
ICH2CONH2
Poids moleculaire
184.96
Point de fusion
92-95°(dried)
Storage & Sensitivity
Keep Cold. Light Sensitive.
Solubilité
Soluble in water, dimethyl formamide and ethanol. Slightly soluble in methanol.

Applications

Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.

Notes

Store in a cool place. Light and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Références bibliographiques

Zbancioc, G.; Mangalagiu, I. I.; Moldoveanu, C. Ultrasound assisted synthesis of imidazolium salts: An efficient way to ionic liquids. Ultrason. Sonochem. 2015, 23, 376-384.

Moriyama, M.; Metzger, S.; van der Vlies, A. J.; Uyama, H.; Ehrbar, M.; Hasegawa, U. Inhibition of Angiogenesis by Antioxidant Micelles. Adv. Healthcare Mater. 2013, 4 (4), 569-575.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H301-H314-H317-H334-H335

Toxic if swallowed. Causes severe skin burns and eye damage. May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation.

Mentions de prudence: P260-P264b-P270-P271-P272-P280-P285-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves/protective clothing/eye protection/face protection. In case of inadequate ventilation wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Autres références

Beilstein
1739080
Classe de danger
6.1
Groupe d'emballage
III
Code tarifaire harmonisé
2924.19
TSCA
Yes
RTECS
AC4200000

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Catalyseurs

Analytique et matériel de laboratoire