Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

431-35-6 - 1-Bromo-3,3,3-trifluoroacetone, 97% - 3-Bromo-1,1,1-trifluoroacetone - 1-Bromo-3,3,3-trifluoro-2-propanone - A14948 - Alfa Aesar

A14948 1-Bromo-3,3,3-trifluoroacetone, 97%

Numéro CAS
431-35-6
Synonymes
3-Bromo-1,1,1-trifluoroacetone
1-Bromo-3,3,3-trifluoro-2-propanone

Dimensions Prix ($) Quantité Disponibilité
5g 35,37
25g 145,80
100g 439,20
Ajouter au panier Ajouter au devis en vrac Afficher l'article

1-Bromo-3,3,3-trifluoroacetone, 97%

MDL
MFCD00039237
EINECS
207-071-9

Propriétés chimiques

Formule
BrCH2COCF3
Poids formulaire
190.95
Point de fusion
<-80°
Point d'ébullition
85-87°
Point d'éclair
-2°(28°F)
Densité
1.822
Indice de réfraction
1.3760
Solubilité
Immiscible with water.

Applications

1-Bromo-3,3,3-trifluoroacetone is used in the preparation of 3-nonylthio-1,1,1-trifluoropropan-2-one and perfluoroalkylated trans-allylic alcohols. It is involved in the synthesis of cyclic tetrapeptides. Further, it reacts with potassium enolate of ethyl 4,4,4-trifluoroacetoacetate to produce ethyl 2,4-bis(trifluoromethyl)-4-hydroxydihydro-3-furoate.

Notes

Incompatible with strong oxidizing agents and bases.

Références bibliographiques

A novel reductive olefination reaction with aldehydes, mediated by Ti(O-i-Pr)4 and PPh3, provides a one-pot synthesis of trifluoromethylated trans-allylic alcohols: Chem. Commun., 2195 (1998):

The oxime is readily converted with base to the highly reactive species 1,1,1-trifluoro-2-nitroso-2-propene, which undergoes hetero-Diels-Alder reactions, e.g. with cyclopentadiene or indole to give fused oxazolines. The indole adduct rearomatizes to give 1-(3-indolyl)-3,3,3-trifluoroacetoxime: J. Org. Chem., 57, 339 (1992).

Hiraoka, Y.; Kawasaki-Takasuka, T.; Morizawa, Y.; Yamazaki, T. Synthetic utility of 2,3,3,3-tetrafluoroprop-1-ene (HFO-1234yf). J. Fluorine Chem. 2015, 179, 71-76.

Dalmal, T.; Appalanaidu, K.; Kosurkar, U. B.; Jagadeesh Babu, N.; Kumbhare, R. M. One-Pot Synthesis of 2-Imino-4-(trifluoromethyl)thiazolidin-4-ol Derivatives in a Three-Component Reaction: Application to Structurally Diverse Scaffolds of Biological Interest Through Subsequent Reactions. Eur. J. Org. Chem. 2014, 2014 (12), 2468-2479.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1703387
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2914.70
TSCA
No

Recommandé

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire