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1899-93-0 - m-Toluenesulfonyl chloride, 98% - 3-Methylbenzenesulfonyl chloride - A15458 - Alfa Aesar

A15458 m-Toluenesulfonyl chloride, 98%

Numéro CAS
1899-93-0
Synonymes
3-Methylbenzenesulfonyl chloride

Dimensions Prix ($) Quantité Disponibilité
1g 20,48
5g 49,25
25g 195,00
100g 561,60
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m-Toluenesulfonyl chloride, 98%

MDL
MFCD00051747

Propriétés chimiques

Formule
C7H7ClO2S
Poids formulaire
190.65
Point d'ébullition
252-253°
Point d'éclair
107°(224°F)
Densité
1.314
Indice de réfraction
1.5480
Sensibilité
Moisture Sensitive
Solubilité
Reacts with water.

Applications

Reactant involved in they synthesis of biologically active molecules including small molecule ligands for the Stat3 SH2 domain, aryldisulfonamides with antibacterial activity, quinazoline analogs for the treatment of Gaucher disease, 17β-HSD2 inhibitors for the treatment of osteoporosis, isoindoline-5-propenehydroxamates for use as histone deactylase inhibitors.

Notes

Moisture sensitive. Store under inert gas. Store away from moisture, oxidizing agents.

Références bibliographiques

Wen-Hsing Lin; Shu-Yi Hsieh; Shih-Chieh Yen; Chiung-Tong Chen; Teng-Kuang Yeh; Tsu Hsu; Cheng-Tai Lu; Ching-Ping Chen; Chun-Wha Chen; Ling-Hui Chou; Yu-Lin Huang; An-Huei Cheng; Yun-I Chang; Ya-Ju Tseng; Kuei-Rong Yen; Yu-Sheng Chao; John T.-A. Hsu; Weir-Torn Jiaang. Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorganic & Medicinal Chemistry. 2011, 19 (14), 4173-4182.

Brent D G Page; Steven Fletcher; Peibin Yue; Zhihua Li; Xiaolei Zhang; Sumaiya Sharmeen; Alessandro Datti; Jeffrey L Wrana; Suzanne Trudel; Aaron D Schimmer; James Turkson; Patrick T Gunning. Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (18), 5605-5609.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
2087865
Classe de danger
8
Groupe d'emballage
II
Code tarifaire harmonisé
2904.90
TSCA
No

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Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire