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7681-82-5 - Sodium iodide, 99+% (dry wt., water <1.0%) - A15480 - Alfa Aesar

A15480 Sodium iodide, 99+% (dry wt., water <1.0%)

Numéro de CAS

Conditionnement Prix ($) Quantité Disponibilité
100g 35,40
500g 135,00
2500g 527,00
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Sodium iodide, 99+% (dry wt., water <1.0%)


Propriétés chimiques

Poids moleculaire
Point de fusion
Point d'ébullition
Indice de réfraction
Very soluble in water and liquid ammonia. Freely soluble in acetone, formic acid, formamide, methanol, and acetonitrile. Soluble in N,N-dimethylformamide.


Sodium iodide is widely used for halide exchange (Finkelstein reaction), for example in the conversion of an alkyl chloride, allyl chloride and arylmethyl chloride into their respective iodides, which are precursors for pharmaceutical and fine chemical products. They are used to ehnance the efficiency of the formation of Wittig adducts from less reactive chlorides and bromides. Appropriate prepartions find use as a nutrient supplement. Sodium iodide is used as the precursor to the control agent in ab initio emulsion polymerization. Sodium iodide finds use in the determination of dissolved oxygen in the modified Winkler method, synthesis of the fluorescent dye coppersensor-1 (CS1) for imaging labile copper pools in biological samples, and the cleavage of esters, lactones, carbamates and ethers in combination with chlorotrimethylsilane.


Deliquescent. Store in a tightly closed container. Incompatible with strong oxidizing agents and acids.

Références bibliographiques

Converts alkyl chlorides or bromides to iodides (Finkelstein reaction). Preferred solvents are acetone or MEK, in which NaI, but not the chloride or bromide, is soluble. See, e.g.: Org. Synth. Coll., 2, 476 (1955); 4, 84 (1963). Activated aryl halides, such as 1-chloro-2,4-dinitrobenzene can be converted to iodides by reaction with NaI in DMF: Org. Synth. Coll., 5, 478 (1973).

Frequently used in catalytic amounts to increase the rate of nucleophilic displacement reactions of alkyl halides and sulfonates; see, for example: Org. Synth. Coll., 9, 46 (1998).

Ethers can be cleaved to ω-iodo esters with a combination of NaI and an acyl chloride: Tetrahedron Lett., 23, 681 (1982). Cleavage of ethers also occurs in the presence of TMS chloride: Angew. Chem. Int. Ed., 20, 690 (1981); J. Org. Chem., 44, 1247 (1979); 48, 3667 (1983). The same combination also reduces benzylic alcohols to arylmethanes: Tetrahedron Lett., 28, 3817 (1987); Bull. Chem. Soc. Jpn., 62, 3537 (1989) and deprotects MEM ethers: Tetrahedron Lett., 25, 1429 (1984); see 2-Methoxyethoxymethyl­ chloride, L01050.

In combination with Titanium(IV)­ chloride, 14713, reduction of amine oxides and nitrones occurs: Chem. Ber., 123, 647 (1990). Similarly, sulfoxides are reduced to sulfides: Synthesis, 155 (1991), and mild reductive deoximation can be effected: Synth. Commun., 21,1777 (1991).

Penheiter, A. R.; Russell, S. J.; Carlson, S. K. The Sodium Iodide Symporter (NIS) as an Imaging Reporter for Gene, Viral, and Cell-based Therapies. Curr. Gene Ther. 2012, 12, (1), 33-47.

Tonnar, J.; Lacroix-Desmazes, P. Use of Sodium Iodide as the Precursor to the Control Agent in Ab Initio Emulsion Polymerization. Angew. Chem. Int. Ed. 2008, 47, 1294-1297.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H303-H315-H319-H335

May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Mentions de prudence: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Code tarifaire harmonisé


  • A10552

    Sodium bromide, 99+% (dry wt.), water <1.0%
  • A10772

    Triethylene glycol, 99%
  • 11414

    Silver nitrate, ACS, 99.9+% (metals basis)
  • 13408

    Lithium bromide, anhydrous, 99% min
  • 36444

    Sodium bromide, ACS, 99.0% min

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