Consentement d'utilisation des Cookies

J'accepte Notre site sauvegarde des traceurs textes (cookies) sur votre appareil afin de vous garantir de meilleurs contenus et à des fins de collectes statistiques.Vous pouvez désactiver l'usage des cookies en changeant les paramètres de votre navigateur. En poursuivant votre navigation sur notre site sans changer vos paramètres de navigateur vous nous accordez la permission de conserver des informations sur votre appareil.

36239-09-5 - Ethyl malonyl chloride, 95% - Ethyl (chloroformyl)acetate - Malonic acid monoethyl ester chloride - A15616 - Alfa Aesar

A15616 Ethyl malonyl chloride, 95%

Numéro CAS
36239-09-5
Synonymes
Ethyl (chloroformyl)acetate
Malonic acid monoethyl ester chloride

Dimensions Prix ($) Quantité Disponibilité
5g 50,40
25g 175,00
100g 561,00
Ajouter au panier Ajouter au devis en vrac Afficher l'article

Ethyl malonyl chloride, 95%

MDL
MFCD00000736
EINECS
252-934-5

Propriétés chimiques

Formule
C5H7ClO3
Poids formulaire
150.56
Point d'ébullition
83°/22mm
Point d'éclair
67°(152°F)
Densité
1.189
Indice de réfraction
1.4290
Sensibilité
Moisture Sensitive
Solubilité
Miscible with water.

Applications

Ethyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

Notes

Store in cool place. Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with alcohols. It reacts with water.

Références bibliographiques

Useful synthetic building block, e.g. in an oxazole synthesis: J. Med. Chem., 36, 3871 (1993):

Formation of amides has been used in the syntheses of 1,2,4-triazine-3,6-diones, and of a vicinal tricarbonyl amide derivative of L-phenylalanine: J. Org. Chem., 60, 5992 (1995); 61, 1872 (1996).

Yang, Z.; Li, S.; Zhang, Z.; Xu, J. Base-switched annuloselectivity in the reactions of ethyl malonyl chloride and imines. Org. Biomol. Chem. 2014, 12 (48), 9822-9830.

Hayat, F.; Kang, L.; Lee, C. Y.; Shin, D. Synthesis of arylnaphthalene lignan lactone using benzoin condensation, intramolecular thermal cyclization and Suzuki coupling. Tetrahedron 2015, 71 (19), 2945-2950.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Mentions de prudence: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
636215
Classe de danger
8
Groupe d'emballage
II
Code tarifaire harmonisé
2917.19
TSCA
No

Recommandé

  • A10655

    1-Bromopinacolone, 97+%
  • A13203

    Propionitrile, 99%
  • A13292

    Sodium bis(2-methoxyethoxy)aluminum hydride, 70% w/w in toluene.
  • A13543

    Guanidine hydrochloride, 98%
  • 40191

    Phosphorus(III) bromide, 99% (metals basis)

Consulté récemment

Produits chimiques

Sciences de la vie

Métaux et matériaux

Catalyseurs

Analytique et matériel de laboratoire