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98-58-8 - 4-Bromobenzenesulfonyl chloride, 98+% - A15909 - Alfa Aesar

A15909 4-Bromobenzenesulfonyl chloride, 98+%

Numéro CAS
98-58-8
Synonymes

Dimensions Prix ($) Quantité Disponibilité
25g 49,30
100g 137,00
500g 490,00
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4-Bromobenzenesulfonyl chloride, 98+%

MDL
MFCD00007437
EINECS
202-683-2

Propriétés chimiques

Formule
C6H4BrClO2S
Poids formulaire
255.52
Point de fusion
73-77°
Point d'ébullition
152-154°/26mm
Sensibilité
Moisture Sensitive
Solubilité
Soluble in Tetrahydrofuran, petroleum ether and 1,4-dioxane. Insoluble in water.

Applications

4-Bromobenzenesulfonyl chloride is used as activating agent in the synthesis of oligodeoxyribo- and oligoribo- nucleotides in solution. It also used in the synthesis of 4-(N-allylsulfamoyl)phenylboronic acid and in protection of amines as 4-bromobenzenesulfonamides.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Store under inert gas.

Références bibliographiques

Reese CB.; Pei-Zhuo Z. J. Phosphotriester approach to the synthesis of oligonucleotides: a reappraisal.. Chem. Soc. Perkin Trans. I. 1993, 1 (9), 2291-2301.

Xiaobao Li.; Justin Pennington.; John F Stobaugh.; Christian Schöneich. Synthesis of sulfonamide- and sulfonyl-phenylboronic acid-modified silica phases for boronate affinity chromatography at physiological pH. Analytical Biochemistry. 2008, 372 (2), 227-236.

Used in protection of amines as 4-bromobenzenesulfonamides: Synth. Commun., 18, 1615 (1988); Tetrahedron Lett., 30, 2399 (1989).

Alcohols are converted to 4-brombenzenesulfonate ("brosylate") esters with enhanced leaving group ability relative to the commoner tosylate; see, e.g.: Carbohydr. Res., 46, 53 (1976).

In the presence of potassium carbonate and a phase-transfer catalyst, N,N'-disubstituted ureas are dehydrated to carbodiimides in high yield: Synthesis, 520 (1987).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Merck
14,1407
Beilstein
743518
Classe de danger
8
Groupe d'emballage
II
Code tarifaire harmonisé
2904.99
TSCA
Yes

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Catalyseurs

Analytique et matériel de laboratoire