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106-96-7 - Propargyl bromide, 80% in toluene, stab. with MgO - 3-Bromo-1-propyne - A16580 - Alfa Aesar

A16580 Propargyl bromide, 80% in toluene, stab. with MgO

Numéro CAS
106-96-7
Synonymes
3-Bromo-1-propyne

Dimensions Prix ($) Quantité Disponibilité
50ml 50,88
250ml 176,13
1000ml 623,15
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Propargyl bromide, 80% in toluene, stab. with MgO

MDL
MFCD00000241
EINECS
203-447-1

Propriétés chimiques

Formule
HC≡CCH2Br
Poids formulaire
118.97
Point de fusion
-61°
Point d'ébullition
88-90°
Point d'éclair
3°(37°F)
Densité
1.335
Indice de réfraction
1.4940
Sensibilité
Light Sensitive
Solubilité
Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.

Applications

Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

Notes

Light sensitive. Store in a cool place. Incompatible withbases, strong oxidizing agents, copper, peroxides, silver, silver oxides, mercury and mercury oxides.

Références bibliographiques

Li, Y.; Cheng, B. One-pot synthesis of precise polyisoxazoles by click polymerization: Copper (I)-catalyzed 1, 3-dipolar cycloaddition of nitrile oxides with alkynes. J. Polym. Sci. A Polym. Chem. 2013, 51 (7), 1645-1650.

Un, I.; Ibisoglu, H.; Un, S. S.; Cosut, B.; Kılıc, A. Syntheses, characterizations, thermal and photophysical properties of cyclophosphazenes containing adamantane units. Inorg. Chim. Acta 2013, 399, 219-226.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H301-H335-H336-H304-H361-H373-H314

Highly flammable liquid and vapour. Toxic if swallowed. May cause respiratory irritation. May cause drowsiness or dizziness. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Causes severe skin burns and eye damage.

Mentions de prudence: P210-P260-P201-P261-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
605309
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2903.39
TSCA
Yes
RTECS
UK4375000

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