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431-47-0 - Methyl trifluoroacetate, 98+% - Trifluoroacetic acid methyl ester - A17338 - Alfa Aesar

A17338 Methyl trifluoroacetate, 98+%

Numéro de CAS
431-47-0
Synonymes
Trifluoroacetic acid methyl ester

Conditionnement Prix ($) Quantité Disponibilité
50g 53,90
250g 238,00
1000g 829,00
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Methyl trifluoroacetate, 98+%

MDL
MFCD00000417
EINECS
207-074-5

Propriétés chimiques

Formule
CF3CO2CH3
Poids moleculaire
128.05
Point de fusion
-78°
Point d'ébullition
43-44°
Point d'éclair
-18°(-0.4°F)
Densité
1.283
Indice de réfraction
1.2900
Sensibilité
Moisture Sensitive
Solubilité
Not miscible or difficult to mix in water.

Applications

Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, has also been used for the N-acylation of amino acids. It is used as an intermediate in the synthesis of pharmaceutical and agricultural chemicals. The chemical reactions usually involve nucleophilic substitution of the ester and are useful for the preparation of trifluoroacylated compounds.

Notes

Moisture sensitive. Store away from strong bases, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.

Références bibliographiques

Langlois BR and Roques N. Nucleophilic trifluoromethylation of aryl halides with methyl trifluoroacetate.J. Fluor. Chem.,2007,128(10), 1318-1325.

M. N. Vargaftik, et al. Highly selective partial oxidation of methane to methyl trifluoroacetate.J. Chem. Soc., Chem. Commun.,1990,15, 1049-1050.

Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, A12314, has also been used for the N-acylation of amino acids: Synthesis, 399 (1976).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
1756070
Classe de danger
3
Groupe d'emballage
II
Code tarifaire harmonisé
2915.90
TSCA
Yes

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Catalyseurs

Analytique et matériel de laboratoire