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117-08-8 - Tetrachlorophthalic anhydride, 98% - A17404 - Alfa Aesar

A17404 Tetrachlorophthalic anhydride, 98%

Numéro de CAS
117-08-8
Synonymes

Conditionnement Prix ($) Quantité Disponibilité
500g 36,00
2500g 128,00
10000g 428,00
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Tetrachlorophthalic anhydride, 98%

MDL
MFCD00005920
EINECS
204-171-4

Propriétés chimiques

Formule
C8Cl4O3
Poids moleculaire
285.90
Point de fusion
254-258°
Point d'ébullition
349-354°
Point d'éclair
362°(683°F)
Sensibilité
Moisture Sensitive
Solubilité
Hydrolyzes slowly in water.

Applications

Protection of amines as their tetrachlorophthalimide derivatives, by reaction with the anhydride in the presence of triethylamine, has been found to be useful in oligosaccharide chemistry. The group is stable to a wide range of reagents but can be selectively cleaved with ethylenediamine at lower temperatures than for the parent phthalimide derivatives; in particular, carboxylic esters are not cleaved under these conditions.

Notes

Hygroscopic. Store away from oxidizing agents, acids.

Références bibliographiques

Wilfred Howe, A.F.O.M., M.R.C.G.P.; Katherine M. Venables, M.Sc., M.R.C.P.; Michael D. Topping, Ph.D.; Michael B. Dally, M.R.A.C.P.; Rosemarie Hawkins, S.R.N.; J.Stephen Law, M.D.; Anthony J.Newman Taylor, M.Sc., M.R.C.P. Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody Journal of Allergy and Clinical Immunology. 1983, 71 (1), 5-11.

Gary M. Liss, MD, MS, FRCPC.; David Bernstein, MD.; Leon Genesove, MD, FRCPC.; Jaan O. Roos, MD, FRCPC.; Janet Lim, MD. Assessment of risk factors for IgE-mediated sensitization to tetrachlorophthalic anhydride. Journal of Allergy and Clinical Immunology. 1993, 92 ( 237-247),.

Protection of amines as their tetrachlorophthalimide derivatives, by reaction with the anhydride in the presence of triethylamine, has been found to be useful in oligosaccharide chemistry. The group is stable to a wide range of reagents but can be selectively cleaved with ethylenediamine at lower temperatures than for the parent phthalimide derivatives; in particular, carboxylic esters are not cleaved under these conditions: J. Am. Chem. Soc., 117, 3302 (1995); J. Org. Chem., 61, 432 (1996).

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H318-H334-H317

Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.

Mentions de prudence: P284-P261-P280a-P305+P351+P338-P310a-P501a

Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Dispose of contents/container in accordance with local/regional/national/international regulations.

Autres références

Beilstein
211560
Classe de danger
9
Groupe d'emballage
III
Code tarifaire harmonisé
2917.39
TSCA
Yes
RTECS
TI3450000

Recommandé

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Catalyseurs

Analytique et matériel de laboratoire