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503-38-8 - Trichloromethyl chloroformate, 98% - Chloroformic acid trichloromethyl ester - Diphosgene - A17444 - Alfa Aesar

A17444 Trichloromethyl chloroformate, 98%

Numéro CAS
503-38-8
Synonymes
Chloroformic acid trichloromethyl ester
Diphosgene

Dimensions Prix ($) Quantité Disponibilité
10g 41,95
50g 159,65
250g 478,80
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Trichloromethyl chloroformate, 98%

MDL
MFCD00015553
EINECS
207-965-9

Propriétés chimiques

Formule
C2Cl4O2
Poids formulaire
197.83
Point de fusion
-57°
Point d'ébullition
128°
Point d'éclair
>110°(230°F)
Densité
1.640
Indice de réfraction
1.4570
Sensibilité
Moisture Sensitive
Solubilité
Miscible with ethanol, ether and benzene. Immiscible with water.

Applications

Trichloromethyl chloroformate is used as a reagent in the synthesis of organic compounds. It serves as a source of phosgene used in some laboratory preparations. Also, it is used as a reactant for the synthesis of cyclic carbamimidates, N-alkenyl and cycloalkyl carbamates and prostate-specific membrane antigen-targeted anticancer prodrugs. In addition, it is involved in the preparation of an erythromycin A derivatives and antibody-drug conjugates. It is utilized in the conversion of amines, carboxylic acids, formamides in to isocyanates, acid chlorides and isocyanides respectively.

Notes

Special handling precautions required. View MSDS prior to purchase. MSDS are available online at www.alfa.comStore in a cool place. Light and heat sensitive. Incompatible with strong oxidizing agents and bases.

Références bibliographiques

Convenient replacement for phosgene in many reactions, for example:

Conversion of amines to isocyanates: J. Org. Chem., 41, 2070 (1976); Org. Synth. Coll ., 6, 715 (1988). For aliphatic amines, best results were obtained in the presence of the hindered amine 1,8-Bis(dimethyl­amino)­naphthalene, L00313: J. Org. Chem., 61, 3883 (1996).

Dehydration of N-monosubstituted formamides to isocyanides: Angew. Chem. Int. Ed., 16, 259 (1977).

Formation of nitriles from oximes Synthesis, 1037 (1986); or carboxamides: Tetrahedron Lett., 27, 2203 (1986).

See also Triphosgene, A14932, and Oxalyl­ chloride, A18012.

Lezama, J.; Domínguez, R. M.; Chuchani, G. Kinetics of the Gas-Phase Elimination Reaction of Benzyl Chloroformate and Neopentyl Chloroformate. Int. J. Chem. Kinet. 2015, 47 (2), 104-112.

Prousis, K. C.; Markopoulos, J.; Mckee, V.; Igglessi-Markopoulou, O. An efficient synthetic approach towards fully functionalized tetronic acids: the use of 1, 3-dioxolane-2, 4-diones as novel protected-activated synthons of α-hydroxy acids. Tetrahedron 2015, 71 (45), 8637-8648.

Mentions de danger et de prudence du SGH

Mentions de danger (UE): H330-H314-H318

Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.

Mentions de prudence: P280-P303+P361+P353-P305+P351+P338-P304+P340-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician.

Autres références

Merck
14,3334
Beilstein
970225
Classe de danger
6.1
Groupe d'emballage
I
Code tarifaire harmonisé
2915.90
TSCA
Yes
RTECS
LQ7350000

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